ReviewNeurochemical research2011
Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation.
Review in Neurochemical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Consistent self-organized emergence of hyaline cartilage in human induced pluripotent stem cell-derived multi-tissue organoids.Stem cells (Dayton, Ohio) · 2025Article
- The multifaceted roles of ZIC genes in cancer: from development regulators to cancer modulators.Discover oncology · 2025Review
- Extracellular Matrix Proteins Differentiate Postnatal Mouse Retina Neurospheres into Neurons or Glia Profiles.Neurochemical research · 2025Article
- Lactate promotes H3K18 lactylation in human neuroectoderm differentiation.Cellular and molecular life sciences : CMLS · 2024Article
- Temporal transcriptional control of neural induction in human induced pluripotent stem cells.Frontiers in molecular neuroscience · 2023Article
- Restorative Mechanism of Neural Progenitor Cells Overexpressing Arginine Decarboxylase Genes Following Ischemic Injury.Experimental neurobiology · 2019Article
- Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.Developmental biology · 2017Article
- BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma.PLoS genetics · 2015Article
- Changing Faces of Transcriptional Regulation Reflected by Zic3.Current genomics · 2015Article
- Retinoic acid signaling and neuronal differentiation.Cellular and molecular life sciences : CMLS · 2015Review
- Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Colorectal polyp model established by transplacental BMP4 RNAi.Molecular medicine reports · 2014Article
- Genome wide analysis reveals Zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish.PLoS genetics · 2013Article
- The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- Ethanol diverts early neuronal differentiation trajectory of embryonic stem cells by disrupting the balance of lineage specifiers.PloS one · 2013Article
- A stable cranial neural crest cell line from mouse.Stem cells and development · 2012Article
- The calcium: an early signal that initiates the formation of the nervous system during embryogenesis.Frontiers in molecular neuroscience · 2012Article
- Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than a decade has passed since Zic family zinc finger proteins were discovered to be transcription factors controlling neuroectodermal differentiation (neural induction) in Xenopus laevis embryos. Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation, recent studies have revealed that FGF signaling and intracellular calcium elevation are also involved in regulating the expression of Zic genes. Different regulatory mechanisms have been found for the Zic1 and Zic3 genes, raising the possibility that functional synergism between them partly accounts for the integration of BMP-signal blocking and FGF signaling in neuroectodermal differentiation. Furthermore, mammalian Zic1 and Zic3 have been found to be neural-cell-fate-inducing and pluripotency-maintaining factors, respectively, leading us to the intriguing question of whether the mechanism underlying amphibian neuroectodermal differentiation is applicable to mammals. Comprehensive understanding of the Zic family genes is therefore essential for the study of the neuroectodermal differentiation and stem cell biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.