ArticlePediatric nephrology (Berlin, Germany)2011
Uncharted waters: nephrogenesis and renal regeneration in fish and mammals.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 15. Fish urinary system.Journal of toxicologic pathology · 2026Article
- Cage-Farming Causes Histopathological Alterations in the Renal Tissues of the Rainbow TroutInternational journal of molecular sciences · 2025Article
- Somites are a source of nephron progenitors in zebrafish.Nature communications · 2025Article
- (Zebra)fishing for nephrogenesis genes.Tissue barriers · 2024Review
- Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023Review
- Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.Journal of developmental biology · 2023Review
- Kidney transcriptome and cystic kidney disease genes in zebrafish.Frontiers in physiology · 2023Article
- Experimental models of acute kidney injury for translational research.Nature reviews. Nephrology · 2022Review
- Acute kidney injury in children with chronic kidney disease is associated with faster decline in kidney function.Pediatric nephrology (Berlin, Germany) · 2021Article
- Effects of sublethal and realistic concentrations of the commercial herbicide atrazine in Pacu (Veterinary world · 2020Article
- Outcomes of prenatally diagnosed solitary functioning kidney during early life.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Postembryonic Nephrogenesis and Persistence of Six2-Expressing Nephron Progenitor Cells in the Reptilian Kidney.PloS one · 2016Article
- Volumetric measurement of compensatory hypertrophy in the contralateral normal kidney by the tumor growth.World journal of urology · 2016Article
- Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2015Article
- MiR-21 is required for efficient kidney regeneration in fish.BMC developmental biology · 2015Article
- Tissue-Engineering Approaches to Restore Kidney Function.Current diabetes reports · 2015Review
- Zebrafish Models of Kidney Damage and Repair.Current pathobiology reports · 2015Article
- Adult stem-like cells in kidney.World journal of stem cells · 2015Review
- Mechanisms of disease reversal in focal and segmental glomerulosclerosis.Advances in chronic kidney disease · 2014Review
- Using zebrafish to study podocyte genesis during kidney development and regeneration.Genesis (New York, N.Y. : 2000) · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major functions of the vertebrate kidney are the removal of metabolic waste and the balance of salt and water. These roles are fulfilled by nephrons, which generally comprise a blood filter (glomerulus) attached to an epithelial tubule. The number of nephrons in the mammalian kidney is set at the end of kidney organogenesis in the late fetal or neonatal period. Subsequent increases in nephron size and functionality then occur during postnatal growth to match increases in body mass/fluid. Because of this strategy of renal development, injuries or birth defects that reduce nephron number lead to a permanent nephron deficit and increase the risk of kidney disease. In contrast to mammals, fish kidneys continue to add nephrons throughout their lifespan. In response to renal injury, fish increase the rate of nephrogenesis, effectively replacing lost nephrons and maintaining their nephron endowment. A better understanding of the remarkable nephrogenic abilities of fish kidneys may lead to innovative ways to restore nephrogenesis in the adult mammalian kidney. This review examines our current understanding of nephrogenesis in mammals and fish and explores possible explanations for why fish, but not mammals, utilize a perpetual nephrogenesis strategy to grow and maintain their kidneys.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.