Trial reportJournal of neuro-oncology2011
Characteristics and prognosis of patients with colorectal cancer-associated brain metastases in the era of modern systemic chemotherapy.
Trial report in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Survival Outcome of Surgical Resection vs. Radiotherapy in Brain Metastasis From Colorectal Cancer: A Meta-Analysis.Frontiers in medicine · 2022Pooled it
- A systematic review to assess the management of patients with cerebral metastases secondary to colorectal cancer.Techniques in coloproctology · 2017Pooled it
- Systematic review: brain metastases from colorectal cancer--Incidence and patient characteristics.BMC cancer · 2016Pooled it
- Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes.World journal of gastrointestinal pathophysiology · 2025Article
- Characteristics and outcome of patients with brain metastases from colorectal cancer.Neuro-oncology practice · 2025Article
- Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis.Oncology letters · 2025Article
- The METACER national cohort study of brain metastases in gastrointestinal cancers prospectively establishes prognostic factors.Journal of neuro-oncology · 2025Article
- Surgical excision and radiotherapy for brain metastasis from colorectal cancer: How frailty and comorbidity indices influence outcome.The Kaohsiung journal of medical sciences · 2024Article
- Prognostic factors associated with the transition in treatment methods for brain metastases from colorectal cancer.International journal of clinical oncology · 2023Article
- Review
- Brain metastases from primary colorectal cancer: is radiosurgery an effective treatment approach? Results of a multicenter study of the radiation and clinical oncology Italian association (AIRO).The British journal of radiology · 2020Article
- Article
- Long-Term Outcomes of Radical Surgery for Transverse Colon Cancer Staged from I to IIIC.Cancer management and research · 2020Article
- Systematic review: Incidence, risk factors, survival and treatment of bone metastases from colorectal cancer.Journal of bone oncology · 2018Review
- Clinical characteristics and treatment outcomes of patients with colorectal cancer who develop brain metastasis: a single institution experience.Journal of gastrointestinal oncology · 2017Article
- Brain metastases in gastrointestinal cancers: is there a role for surgery?International journal of molecular sciences · 2014Review
- Impact of systemic treatment on survival after whole brain radiotherapy in patients with brain metastases.Medical oncology (Northwood, London, England) · 2014Article
- Brain metastases from colorectal cancer: main clinical factors conditioning outcome.International journal of colorectal disease · 2014Article
- HER-2 Expression in Brain Metastases from Colorectal Cancer and Corresponding Primary Tumors: A Case Cohort Series.International journal of molecular sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain metastases (BM) occur in approximately 20-40% of cancer patients. The present study investigated the clinical outcomes of patients with BM from colorectal cancer (CRC) to assess the benefit of systemic chemotherapy (CT) administered after surgical or radiotherapeutic control of BM and to identify independent prognostic factors associated with survival after BM. Between August 2001 and July 2009, 118 patients with symptomatic BM from CRC received either cranial irradiation or craniotomy at two large cancer centers in South Korea. Retrospective review and statistical analysis of clinical characteristics and outcomes were performed for all patients. Median time from diagnosis of metastatic CRC to detection of BM was 12.2 months (range 0-76.2 months). Thirteen patients (11%) exhibited brain involvement at initial presentation. Median survival after BM development was 4.1 months [95% confidence interval (CI) 3.3-4.9 months]. Forty-six patients (40%) had been treated previously with the chemotherapeutic agents fluoropyrimidine, oxaliplatin, and irinotecan. Patients who received CT after BM exhibited significantly improved survival compared with those who did not (12.4 versus 3.1 months, respectively; P < 0.001). Multivariate analysis revealed that CT intervention after presentation with BM was significantly associated with survival after BM, and the adjusted hazard ratio was 0.30 (95% CI 0.17-0.51, P < 0.001). Although BM is a late-stage phenomenon in CRC, approximately two-thirds of patients were still unexposed to irinotecan or oxaliplatin at the development of BM in our study. Thus, additional chemotherapeutic intervention after BM associated with CRC may be beneficial for selected patients.
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