Evidence map›Paper›PMID 21336679›Full record

Trial reportInternational journal of behavioral medicine2011

Effects of a weight loss intervention on body mass, fitness, and inflammatory biomarkers in overweight or obese breast cancer survivors.

Bilgé Pakiz, Shirley W Flatt, Wayne A Bardwell, Cheryl L Rock, Paul J Mills

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of behavioral medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 15 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 15 syntheses or guidelines pooled it, 104 citations in OpenAlex.

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  7. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  8. Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
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  10. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
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  20. Randomized trial of a clinic-based weight loss intervention in cancer survivors.Journal of cancer survivorship : research and practice · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bilgé PakizDepartment of Family and Preventive Medicine, Moores UCSD Cancer Center, University of California, San Diego, 9500 Gilman Dr. MC 0901, La Jolla, CA 92093-0901, USA. bpakiz@ucsd.edu
Shirley W Flatt
Wayne A Bardwell
Cheryl L Rock
Paul J Mills
University of California, San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is characterized by chronic mild inflammation and may influence the risk and progression of cancer. PURPOSE: The current study is an exploratory analysis of the effect of a weight loss intervention that emphasized increased physical activity on inflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6], interleukin-8 [IL-8], and vascular endothelial growth factor [VEGF]) at the end of the 16-week intervention period in overweight breast cancer survivors.

methodsStudy participants averaged 56 years of age (N=68). Intervention participants (n=44 vs. 24 controls) participated in a cognitive behavioral therapy-based weight management program as part of an exploratory randomized trial. The intervention incorporated strategies to promote increased physical activity and diet modification. Baseline and 16-week data included height, weight, body composition, physical activity level, and biomarkers IL-6, IL-8, TNF-α, and VEGF.

resultsWeight loss was significantly greater in the intervention group than controls (-5.7 [3.5] vs. 0.2 [4.1] kg, P<0.001). Paired t tests noted favorable changes in physical activity level (P<0.001 intervention, P=0.70 control), marginally lower IL-6 levels (P=0.06 intervention, P=0.25 control) at 16 weeks for participants in the intervention group, and lower TNF-α levels for participants in the intervention (P<0.05) and control groups (P<0.001). Increased physical activity was associated with favorable changes in IL-6 for participants in the intervention group (R(2) =0.18; P<0.03).

conclusionFavorable changes in cytokine levels were observed in association with weight loss in this exploratory study with overweight breast cancer survivors.

Indexed as

AdultAgedBiomarkersBody Mass IndexBreast NeoplasmsCaliforniaCognitive Behavioral TherapyFemaleHumansMiddle AgedObesityOverweightPhysical FitnessRegression AnalysisSurvivorsWeight LossBiomarkers

Identifiers

PMID21336679
PMCPMC3212681
OpenAlexW2001143541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.