ReviewPflugers Archiv : European journal of physiology2011
Regional variation in myofilament length-dependent activation.
Review in Pflugers Archiv : European journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- The importance of mechanical conditions in the testing of excitation abnormalities in a population of electro-mechanical models of human ventricular cardiomyocytes.Frontiers in physiology · 2023Article
- Cardiac Sarcomere Signaling in Health and Disease.International journal of molecular sciences · 2022Review
- Contractile State Dependent Sarcomere Length Variability in Isolated Guinea-Pig Cardiomyocytes.Frontiers in physiology · 2022Article
- Measuring the link between cardiac mechanical function and metabolism during hyperpolarizedMagnetic resonance imaging · 2020Article
- Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes.Frontiers in physiology · 2020Article
- What grows together, goes together: assessing variability in cardiomyocyte function.The Journal of physiology · 2019Article
- Length-Dependent Activation of Contractility and Ca-Transient Kinetics in Auxotonically Contracting Isolated Rat Ventricular Cardiomyocytes.Frontiers in physiology · 2019Article
- Voltage dependence of the CaMolecular and cellular biochemistry · 2018Article
- Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy.Journal of molecular and cellular cardiology · 2018Article
- Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.Journal of the American Heart Association · 2016Article
- Mechano-electric heterogeneity of the myocardium as a paradigm of its function.Progress in biophysics and molecular biology · 2016Review
- The cardiac muscle duplex as a method to study myocardial heterogeneity.Progress in biophysics and molecular biology · 2014Review
- Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.Circulation · 2014Article
- Temperature and transmural region influence functional measurements in unloaded left ventricular cardiomyocytes.Physiological reports · 2013Article
- Integrating multi-scale data to create a virtual physiological mouse heart.Interface focus · 2013Article
- Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation.American journal of physiology. Heart and circulatory physiology · 2013Article
- Sacrificial layer technique for axial force post assay of immature cardiomyocytes.Biomedical microdevices · 2013Article
- Mechanobiology in cardiac physiology and diseases.Journal of cellular and molecular medicine · 2013Review
- Interpreting genetic effects through models of cardiac electromechanics.American journal of physiology. Heart and circulatory physiology · 2012Review
- An analysis of deformation-dependent electromechanical coupling in the mouse heart.The Journal of physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Frank-Starling law is an important regulatory mechanism of the heart that links the end-diastolic volume with the systolic ejection fraction. This beat-to-beat regulation of the heart, underlined at the cellular level by higher myofilament calcium sensitivity at longer sarcomere length, is known as length-dependent activation or stretch sensitization of activation. However, the heart is structurally and functionally heterogeneous and asymmetrical. Specifically, contractile properties are not uniform within the left ventricle partly due to transmural differences in action potential waveforms and calcium homeostasis. The present review will focus on the role of the contractile machinery in the transmural contractile heterogeneity and its adaptation to changes in muscle strain. The expression of different myosin isoforms, the level of titin-based passive tension, and thin and thick sarcomeric regulatory proteins are considered to explain the regional cellular contractile properties. Finally, the importance of transmural heterogeneity of length-dependent activation and the consequences of its modification on the heart mechanics are discussed. Despite extensive research since the characterization of the Frank-Starling law, the molecular mechanisms by which strain information is transduced to the contractile machinery have not been fully determined yet.
Indexed as
Identifiers
21336586What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.