ArticleVeterinary research communications2011
Echinococcus granulosus: immunoprotection accompanyied by humoral and cytokine response against secondary hydatidosis in mice immunized with rEg.myophilin.
Article in Veterinary research communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recombinant Echinococcus granulosus myophilin alleviates airway inflammation in mice with ovalbumin-induced allergic asthma via the gut microbiota-metabolite-immune axis.Parasites & vectors · 2026Article
- Induction of Immunogenic Response in BALB/c Mice by Live and Killed Form of Recombinant Lactococcus lactis Displaying EG95 of Echinococcus granulosus.Iranian biomedical journal · 2021Article
- Immunoprotection of recombinant Eg.myophilin againstExperimental and therapeutic medicine · 2016Article
- Immunoprotection of recombinant Eg.P29 against Echinococcus granulosus in sheep.Veterinary research communications · 2016Article
- Mechanism of protective immunity by vaccination with recombinantExperimental and therapeutic medicine · 2015Article
- Induction of protective T-helper 1 immune responses against Echinococcus granulosus in mice by a multi-T-cell epitope antigen based on five proteins.Memorias do Instituto Oswaldo Cruz · 2013Article
- Identification and characterization of myophilin-like protein: a life stage and tissue-specific antigen of Clonorchis sinensis.Parasitology research · 2012Article
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Authors and funding
9 authors.
Funding
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Abstract
objectsThis study aimed to investigate the immunoprotection of the recombinant Eg.myophilin (rEg.myophilin) and tentatively analyze mechanism of this protection. MATERIALS AND
methodThree groups of female mice were immunized subcutaneously with rEg.myophilin and contrasts, after two boosters, mice were challenged with Eg protoscoleces (PSCs) intraperitoneally, and then analyzed the humoral immune response with specific IgG, IgG1, IgG2a, IgG2b, IgG3 and IgE, and also evaluated the cellular immune with IFN-γ, IL-4, IL-10.
resultsMice immunized with rEg.myophilin produced effective immunity protection (reductions in cyst load more than 86.11%). Mice immunized with rEg.myophilin showed specific IgG, IgG1, IgG2a and IgE accompanied by IFN-γ and IL-4 significantly increased after one or more times of immunization, but neither IgG2b nor IgG3 increased. Nevertheless, IL-10 significantly increased in the control groups but a decline trend in rEg.myophilin group.
conclusionsrEg.myophilin showed a effectively protective immunity, which may attribute to: (1) IgGs and IgE-mediated humoral immune response, as well as cell-mediated immunity which was marked by IFN-γ. (2) IL-4 assists to stimulate type transformation of IgE which plays an important role in Eosinophils-related anti-parasite immunity. (3) Immunosuppressive effect (marked by IL-10), the key obstacle to clean of parasites in the patient, was inhibited in the rEg.myophilin group compared with control groups.
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