ReviewClinical reviews in allergy & immunology2011
Pathogenesis of ANCA-associated vasculitis, an update.
Review in Clinical reviews in allergy & immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Cocaine-Triggered PR3-ANCA Vasculitis Localized to a Post-Surgical Neck Field: A Case of Locus Minoris Resistentiae in Drug-Induced Autoimmunity.Diagnostics (Basel, Switzerland) · 2025Article
- Cocaine- and Levamisole-Induced Vasculitis: Defining the Spectrum of Autoimmune Manifestations.Journal of clinical medicine · 2024Review
- Nailfold Capillaroscopy Analysis Can Add a New Perspective to Biomarker Research in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.Diagnostics (Basel, Switzerland) · 2024Review
- Review
- Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review.Yonsei medical journal · 2019Review
- Article
- ANCA-associated vasculitis in childhood: recent advances.Italian journal of pediatrics · 2017Review
- Pathogenesis of antimicrobial peptides LL-37 and CpG-ODN in ANCA associated vasculitis.Journal of nephrology · 2017Article
- Updates in ANCA-associated vasculitis.European journal of rheumatology · 2016Review
- Podocyte Detachment Is Associated with Renal Prognosis in ANCA-Associated Glomerulonephritis: A Retrospective Cohort Study.Medicine · 2016Observational
- Endothelial Response to Glucocorticoids in Inflammatory Diseases.Frontiers in immunology · 2016Review
- The kidneys and ANCA-associated vasculitis: from pathogenesis to diagnosis.Clinical kidney journal · 2015Article
- Pauci-Immune Crescentic Glomerulonephritis: An ANCA-Associated Vasculitis.BioMed research international · 2015Review
- Unmet needs in respiratory diseases : "You can't know where you are going until you know where you have been"--Anonymous.Clinical reviews in allergy & immunology · 2013Review
- A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism.The Journal of biological chemistry · 2013Article
- Does searching for antineutrophil cytoplasmic antibodies help with the diagnosis of Adult-onset Still's disease?Rheumatology international · 2013Article
- Complications of long-term therapy for ANCA-associated systemic vasculitis.Nature reviews. Nephrology · 2012Review
- Toward a new autoantibody diagnostic orthodoxy: understanding the bad, good and indifferent.Auto- immunity highlights · 2012Review
- Article
- Renal limited ANCA-positive vasculitis: a rare manifestation of a rare disease.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical observations, including a report of neonatal vasculitis occurring in a child born from a mother with anti-neutrophil cytoplasmic antibody directed to myeloperoxidase (MPO-ANCA)-associated vasculitis, suggest a pathogenic role for ANCA. Such a role is supported by in vitro experimental data showing that ANCA can activate primed neutrophils to the production of reactive oxygen species and lytic enzymes resulting in lysis of endothelial cells. An interplay between neutrophils, the alternative pathway of complement, and MPO-ANCA resulting in systemic vasculitis including necrotizing glomerulonephritis has clearly been demonstrated in animal models. An in vivo pathogenic role of ANCA directed to proteinase 3 (PR3-ANCA) has, however, not been substantiated. In PR3-ANCA-associated vasculitis, granulomatous inflammation points to involvement of cell-mediated immunity. In vitro studies, indeed, suggest that PR3-specific Th17 CD4-positive lymphocytes are operative in lesion development. The triggering role of microbial factors is becoming more clear. In particular Staphylococcus aureus carriage and infection with Gram-negative bacteria could contribute to induction and persistence of ANCA-associated vasculitis (AAV). Insight into the pathogenic pathways involved in AAV have opened and will further open new ways to targeted treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.