ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2011
Small bowel adenocarcinoma in Crohn's disease.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Small bowel adenocarcinoma in Crohn's disease: a systematic review and meta-analysis of the prevalence, manifestation, histopathology, and outcomes.International journal of colorectal disease · 2022Pooled it
- Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2024 for the Clinical Practice of Inflammatory Bowel Disease-Associated Intestinal Neoplasia (English Version).Journal of the anus, rectum and colon · 2026Review
- Clinical Characteristics and Outcomes of Small Bowel Neoplasms in Crohn's Disease: A Case-Control Study.Crohn's & colitis 360 · 2025Article
- Article
- Multimodality imaging features of small bowel cancers complicating Crohn's disease: a pictorial review.Abdominal radiology (New York) · 2024Review
- Small Bowel Carcinoma in the Setting of Inflammatory Bowel Disease.Clinics in colon and rectal surgery · 2024Review
- Historical Perspectives: Malignancy in Crohn's Disease and Ulcerative Colitis.Clinics in colon and rectal surgery · 2024Review
- Impact of Crohn's Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study.Gut and liver · 2023Article
- Small Bowel Adenocarcinoma in a Patient with Crohn's Disease: The Role of Balloon-Assisted Enteroscopy.GE Portuguese journal of gastroenterology · 2023Article
- Primary adenocarcinoma of an ileostomy in a Crohn patient: a case report.Journal of surgical case reports · 2022Article
- Mucinous Signet-Cell Adenocarcinoma of the Ileum: A Diagnostic Challenge-Case Report and Review of the Literature.Case reports in gastrointestinal medicine · 2022Article
- Review
- Small bowel adenocarcinoma in Crohn's disease: a rare but devastating complication.Techniques in coloproctology · 2020Article
- Crohn's Disease and the Risk of Cancer.Clinics in colon and rectal surgery · 2019Review
- Ileal Adenocarcinoma with Liver Metastasis in Patient with Crohn's Disease: A 9-Year Survival.Case reports in oncological medicine · 2019Article
- Small Bowel Carcinomas Associated with Immune-Mediated Intestinal Disorders: The Current Knowledge.Cancers · 2018Review
- Enterocutaneous fistulas: a primer for radiologists with emphasis on CT and MRI.Insights into imaging · 2017Review
- Small bowel adenocarcinoma complicating Crohn's disease: a single-centre experience emphasizing the importance of screening for dysplasia.Virchows Archiv : an international journal of pathology · 2017Article
- Genetic risks and familial associations of small bowel carcinoma.World journal of gastrointestinal oncology · 2016Review
- Letter to the editor: one point cancer of ileal adenocarcinoma complicated from Crohn's disease.International journal of colorectal disease · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between small bowel adenocarcinoma and Crohn's disease (CD) is well-established. We present our recent experience with this entity in order to further elucidate its clinicopathological features and update our series from 1991.
methodsA retrospective review was undertaken of all surgical patients with small bowel adenocarcinoma and CD seen at our institution between 1993 and 2009. Follow-up was assessed until time of death or by interview with survivors. Survival was calculated based on TNM (tumor extent, lymph node status, metastases staging) staging and comparing between our current and previous series.
resultsTwenty-nine patients (ten females and 19 males) were identified and followed for a median of 2 years. The median age at onset of CD symptoms was 25, and the median age at cancer diagnosis was 55.4, for a mean interval of 25.3 years. Twenty-two cancers were ileal and five were jejunal. There were no cancers in excluded intestinal loops. Significant differences in 2-year survival were determined for: node-negative (79.3%, 95%CI 58.3-100%) versus node-positive cancers (49% %, 95%CI 20.0-78.0%), and for localized (92.3%, 95%CI 77.8-100%) versus metastatic disease (33.3%, 95%CI 6.6-60%). Overall 36-month survival was 69.3% (95%CI 51.5-87.1%) compared to 40% among those without excluded loops in our series from 1991. Sixteen patients had long periods of quiescent disease before diagnosis (7-45 years), and 16 required surgery for bowel obstruction that was refractory to medical management. Adequate information was not retrievable for three patients.
conclusionsA comparison to our previous series reveals similar clinical characteristics and a high rate of node-positive cancer at diagnosis. Our findings also confirm two important clinical indicators of malignancy: recrudescent symptoms after long periods of relative quiescence and small bowel obstruction that is refractory to medical therapy.
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