Evidence map›Paper›PMID 21335621›Full record

Trial reportDiabetes care2011

Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes.

Tadej Battelino, Moshe Phillip, Natasa Bratina, Revital Nimri, Per Oskarsson, Jan Bolinder

2 registry-linked trialsOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 189 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 10 pooled it
25.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01741467 nacompletednot on this mapstarted 2012, after this paper: background citation

The Effect of Real Time Continuous Glucose Monitoring in Subjects With Pre-diabetes

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2012 to 2016Enrolled110ConditionsPre-diabetes, Impaired Glucose ToleranceArmsRT-CGM
NCT01908530 nacompletednot on this mapstarted 2013, after this paper: background citation

Clinical Assessment of a Novel Microprobe Array Continuous Glucose Monitor for Type 1 Diabetes

TypeinterventionalSponsorImperial College LondonRan2013 to 2018Enrolled26ConditionsDiabetes MellitusArmsMicroprobe glucose sensor
3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 10 syntheses or guidelines pooled it, 488 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Guideline
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Screening with urinary dipsticks for reducing morbidity and mortality.The Cochrane database of systematic reviews · 2015
    Pooled it
  8. Continuous glucose monitoring systems for type 1 diabetes mellitus.The Cochrane database of systematic reviews · 2012
    Pooled it
  9. Guideline
  10. Hypoglycemia in critically ill children.Journal of diabetes science and technology · 2012
    Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Tadej BattelinoDepartment of Pediatric Endocrinology, Diabetes and Metabolism, Faculty of Medicine, University Medical Centre-University Children’s Hospital, University of Ljubljana, Ljubljana, Slovenia. tadej.battelino@mf.uni-lj.si
Moshe Phillip
Natasa Bratina
Revital Nimri
Per Oskarsson
Jan Bolinder
Karolinska University Hospital · SETel Aviv University · ILUniversity of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes. RESEARCH DESIGN AND

methodsIn this randomized, controlled, multicenter study, 120 children and adults on intensive therapy for type 1 diabetes and a screening level of glycated hemoglobin A(1c) (HbA(1c)) <7.5% were randomly assigned to a control group performing conventional home monitoring with a blood glucose meter and wearing a masked continuous glucose monitor every second week for five days or to a group with real-time continuous glucose monitoring. The primary outcome was the time spent in hypoglycemia (interstitial glucose concentration <63 mg/dL) over a period of 26 weeks. Analysis was by intention to treat for all randomized patients.

resultsThe time per day spent in hypoglycemia was significantly shorter in the continuous monitoring group than in the control group (mean ± SD 0.48 ± 0.57 and 0.97 ± 1.55 h/day, respectively; ratio of means 0.49; 95% CI 0.26-0.76; P = 0.03). HbA(1c) at 26 weeks was lower in the continuous monitoring group than in the control group (difference -0.27%; 95% CI -0.47 to -0.07; P = 0.008). Time spent in 70 to 180 mg/dL normoglycemia was significantly longer in the continuous glucose monitoring group compared with the control group (mean hours per day, 17.6 vs. 16.0, P = 0.009).

conclusionsContinuous glucose monitoring was associated with reduced time spent in hypoglycemia and a concomitant decrease in HbA(1c) in children and adults with type 1 diabetes.

Indexed as

Blood Glucose Self-MonitoringAdolescentAdultAgedBlood GlucoseChildDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHumansHypoglycemiaMaleMiddle AgedYoung AdultBlood GlucoseGlycated Hemoglobin

Identifiers

PMID21335621
PMCPMC3064030
OpenAlexW2158009484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.