Evidence map›Paper›PMID 21335541›Full record

ReviewJournal of dental research2011

Stick to your gums: mechanisms of oral microbial adherence.

A H Nobbs, H F Jenkinson, N S Jakubovics

Open access · greenAbstract readReview
In one paragraph

Review in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Insights into the enigma of oral streptococci in carcinogenesis.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  14. Review
  15. COClinical oral investigations · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Bacterial biofilms in the human body: prevalence and impacts on health and disease.Frontiers in cellular and infection microbiology · 2023
    Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

A H NobbsSchool of Oral and Dental Sciences, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK.
H F Jenkinson
N S Jakubovics
University of Bristol · GBNewcastle University · GB

Funding

Streptococcus-Candida Communication in Oral BiofilmsR01DE016690 · NIDCR · UNIVERSITY OF BRISTOL · PI JENKINSON, HOWARD F, LAMONT, RICHARD J · 2006 to 2016
$3.8M
NIDCR NIH HHS R01 DE016690Wellcome Trust 081855Wellcome Trust 084979
6 · The paper itself

Abstract

Studies on the adherence properties of oral bacteria have been a major focus in microbiology research for several decades. The ability of bacteria to adhere to the variety of surfaces present in the oral cavity, and to become integrated within the resident microbial communities, confers growth and survival properties. Molecular analyses have revealed several families of Gram-positive bacterial surface proteins, including serine-rich repeat, antigen I/II, and pilus families, that mediate adherence to a variety of salivary and oral bacterial receptors. In Gram-negative bacteria, pili, auto-transporters, and extracellular matrix-binding proteins provide components for host tissue recognition and building of complex microbial communities. Future studies will reveal in greater detail the binding pockets for these adhesin families and their receptors. This information will be crucial for the development of new inhibitors or vaccines that target the functional regions of bacterial proteins that are involved in colonization and pathogenesis.

Indexed as

Adhesins, BacterialAnimalsBacterial AdhesionBacterial Outer Membrane ProteinsDental PellicleGram-Negative BacteriaGram-Positive BacteriaHumansMetagenomeMicrobial InteractionsProtein BindingSalivary Proteins and PeptidesAdhesins, BacterialBacterial Outer Membrane ProteinsSalivary Proteins and Peptides

Identifiers

PMID21335541
PMCPMC3188457
OpenAlexW2120218769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.