ArticleEukaryotic cell2011
Degeneration in codon usage within the region of suppressed recombination in the mating-type chromosomes of Neurospora tetrasperma.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Stepwise recombination suppression around the mating-type locus associated with a diploid-like life cycle in Schizothecium fungi.Molecular biology and evolution · 2026Article
- Dynamics of transposable element accumulation in the non-recombining regions of mating-type chromosomes in anther-smut fungi.Nature communications · 2023Article
- Tempo of Degeneration Across Independently Evolved Nonrecombining Regions.Molecular biology and evolution · 2022Article
- Recombination suppression and evolutionary strata around mating-type loci in fungi: documenting patterns and understanding evolutionary and mechanistic causes.The New phytologist · 2021Review
- Convergent evolution of linked mating-type loci in basidiomycete fungi.PLoS genetics · 2019Article
- Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements.Nature communications · 2018Article
- Fine-Scale Recombination Maps of Fungal Plant Pathogens Reveal Dynamic Recombination Landscapes and Intragenic Hotspots.Genetics · 2018Article
- Introgression maintains the genetic integrity of the mating-type determining chromosome of the fungus Neurospora tetrasperma.Genome research · 2016Article
- Contrasted patterns in mating-type chromosomes in fungi: hotspots versus coldspots of recombination.Fungal biology reviews · 2015Article
- Codon and Amino Acid Usage Are Shaped by Selection Across Divergent Model Organisms of the Pancrustacea.G3 (Bethesda, Md.) · 2015Article
- Chaos of Rearrangements in the Mating-Type Chromosomes of the Anther-Smut Fungus Microbotryum lychnidis-dioicae.Genetics · 2015Article
- Sex and parasites: genomic and transcriptomic analysis of Microbotryum lychnidis-dioicae, the biotrophic and plant-castrating anther smut fungus.BMC genomics · 2015Article
- Degeneration of the nonrecombining regions in the mating-type chromosomes of the anther-smut fungi.Molecular biology and evolution · 2015Article
- Recent and massive expansion of the mating-type-specific region in the smut fungus Microbotryum.Genetics · 2015Article
- Intron evolution in Neurospora: the role of mutational bias and selection.Genome research · 2015Article
- Maintaining two mating types: structure of the mating type locus and its role in heterokaryosis in Podospora anserina.Genetics · 2014Article
- Recent gene-capture on the UV sex chromosomes of the moss Ceratodon purpureus.Evolution; international journal of organic evolution · 2013Article
- Species and population level molecular profiling reveals cryptic recombination and emergent asymmetry in the dimorphic mating locus of C. reinhardtii.PLoS genetics · 2013Article
- Large-scale introgression shapes the evolution of the mating-type chromosomes of the filamentous ascomycete Neurospora tetrasperma.PLoS genetics · 2012Article
- Sex and speciation: the paradox that non-recombining DNA promotes recombination.Fungal biology reviews · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin and early evolution of sex chromosomes are currently poorly understood. The Neurospora tetrasperma mating-type (mat) chromosomes have recently emerged as a model system for the study of early sex chromosome evolution, since they contain a young (<6 million years ago [Mya]), large (>6.6-Mb) region of suppressed recombination. Here we examined preferred-codon usage in 290 genes (121,831 codon positions) in order to test for early signs of genomic degeneration in N. tetrasperma mat chromosomes. We report several key findings about codon usage in the region of recombination suppression, including the following: (i) this region has been subjected to marked and largely independent degeneration among gene alleles; (ii) the level of degeneration is magnified over longer periods of recombination suppression; and (iii) both mat a and mat A chromosomes have been subjected to deterioration. The frequency of shifts from preferred codons to nonpreferred codons is greater for shorter genes than for longer genes, suggesting that short genes play an especially significant role in early sex chromosome evolution. Furthermore, we show that these degenerative changes in codon usage are best explained by altered selection efficiency in the recombinationally suppressed region. These findings demonstrate that the fungus N. tetrasperma provides an effective system for the study of degenerative genomic changes in young regions of recombination suppression in sex-regulating chromosomes.
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