ArticleJournal of bacteriology2011
Elucidation of the regulon and cis-acting regulatory element of HrpB, the AraC-type regulator of a plant pathogen-like type III secretion system in Burkholderia pseudomallei.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Identification of protein secretion systems and type III effectors in wood-associated bacteria of the genusMicrobiology spectrum · 2026Article
- Prevalence and diversity of TAL effector-like proteins in fungal endosymbioticMicrobial genomics · 2024Article
- The HrpG/HrpX Regulon of Xanthomonads-An Insight to the Complexity of Regulation of Virulence Traits in Phytopathogenic Bacteria.Microorganisms · 2021Review
- Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution.Journal of industrial microbiology & biotechnology · 2020Review
- OnfD, an AraC-Type Transcriptional Regulator Encoded byApplied and environmental microbiology · 2020Article
- Type III secretion inhibitors for the management of bacterial plant diseases.Molecular plant pathology · 2019Article
- A Phosphorylation Switch on Lon Protease Regulates Bacterial Type III Secretion System in Host.mBio · 2018Article
- Type III Secretion in the Melioidosis PathogenFrontiers in cellular and infection microbiology · 2017Review
- The post-transcriptional regulator rsmA/csrA activates T3SS by stabilizing the 5' UTR of hrpG, the master regulator of hrp/hrc genes, in Xanthomonas.PLoS pathogens · 2014Article
- Current knowledge on the Ralstonia solanacearum type III secretion system.Microbial biotechnology · 2013Article
- The condition-dependent transcriptional landscape of Burkholderia pseudomallei.PLoS genetics · 2013Article
- RNA-seq and microarray complement each other in transcriptome profiling.BMC genomics · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The human pathogen Burkholderia pseudomallei possesses multiple type III secretion system (T3SS) gene clusters. One of these, the B. pseudomallei T3SS2 (T3SS2(bp)) gene cluster, which apparently plays no role in animal virulence, is also found in six additional Burkholderia spp. and is very similar to T3SSs found in phytopathogenic Xanthomonas spp. and Ralstonia solanacearum. The T3SS2(bp) gene cluster also encodes an AraC-type regulatory protein (HrpB(bp)) that is an ortholog of HrpB, the master regulator of the R. solanacearum T3SS (T3SS(rso)) and its secreted effectors. Transcriptome analysis showed that HrpB(bp) activates the expression of T3SS2(bp) genes, as well as their orthologs in R. solanacearum. In addition to activating T3SS2(bp), HrpB(bp) also upregulates the expression of ~30 additional B. pseudomallei genes, including some that may confer production of adhesive pili, a polyketide toxin, several putative T3SS2(bp)-secreted effectors, and components of a regulatory cascade. T3SS2(bp) promoter regions were found to contain a conserved DNA motif (p2(bp) box) identical in sequence and position to the hrp(II) box required for HrpB-dependent T3SS(rso) transcription activation. The p2(bp) box is also present in the promoter regions of the essentially identical T3SS found in the very closely related species Burkholderia thailandensis (T3SS2(bt)). Analysis of p2(bp) box mutants showed that it is essential for HrpB(bp)-mediated transcription activation in both species. Although it has been suggested that T3SS2(bp) and T3SS2(bt) may function in phytopathogenicity, we were unable to demonstrate a phytopathogenic phenotype for B. thailandensis in three different plant hosts.
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