ArticleNeuroscience letters2011
Activity-dependent slowing properties of an unmyelinated low threshold mechanoreceptor in human hairy skin.
Article in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- Macrophage memories of early-life injury drive neonatal nociceptive priming.Cell reports · 2024Article
- Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice.Brain : a journal of neurology · 2022Article
- Optimal delineation of single C-tactile and C-nociceptive afferents in humans by latency slowing.Journal of neurophysiology · 2017Article
- Tactile C fibers and their contributions to pleasant sensations and to tactile allodynia.Frontiers in behavioral neuroscience · 2014Review
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
It has been previously shown that unmyelinated afferent fibres in human skin are differentiated not only by their receptor characteristics, but also by their profiles of activity-dependent slowing. One type of profile, described originally as 'type 3', is different from that of nociceptors (type 1), cold afferents (type 2) and sympathetic efferents (type 4), in that these fibres display a minimal activity-dependent slowing (∼1% at 2 Hz). However, their function remains to be determined. Here we describe one unit with a typical 'type 3' activity-dependent slowing profile recorded from an undamaged fascicle of the superficial peroneal nerve of a patient. Its conduction velocity was 1.8 m s(-1) and it slowed by 1.3% during the 2 Hz tetanus. This unit had a mechanical receptive field in the hairy skin and responded readily to weak mechanical stimuli, and not to cold. This suggests that the low threshold unmyelinated mechanoreceptors recently described in human hairy skin are probably endowed with a 'type 3' activity-dependent profile.
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Registered trials
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