ArticleBehavioural brain research2011
Dysfunctional play and dopamine physiology in the Fischer 344 rat.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Noradrenergic modulation of play in Sprague-Dawley and F344 rats.Psychopharmacology · 2025Article
- Juvenile male rats form preferences based on strain when playing in groups but not in pairs.Frontiers in behavioral neuroscience · 2025Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- How strain differences could help decipher the neurobiology of mammalian playfulness: What the less playful Fischer 344 rat can tell us about play.International journal of play · 2020Article
- Involvement of orexin/hypocretin in the expression of social play behaviour in juvenile rats.International journal of play · 2020Article
- Effects of neonatal handling on play and anxiety in F344 and Lewis rats.Developmental psychobiology · 2018Article
- Effects of cross-fostering on play and anxiety in juvenile Fischer 344 and Lewis rats.Physiology & behavior · 2017Article
- The neurobiology of social play and its rewarding value in rats.Neuroscience and biobehavioral reviews · 2016Review
- Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome.Translational psychiatry · 2016Article
- Article
- Dose-dependent effects of the antiprogestin, RU486, on sexual behavior of naturally cycling Fischer rats.Behavioural brain research · 2015Article
- Early-life risperidone administration alters maternal-offspring interactions and juvenile play fighting.Pharmacology, biochemistry, and behavior · 2015Article
- Social play behavior, ultrasonic vocalizations and their modulation by morphine and amphetamine in Wistar and Sprague-Dawley rats.Psychopharmacology · 2014Article
- Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior.Frontiers in behavioral neuroscience · 2014Article
- Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat.Neuroscience · 2012Article
- Serotonin, motivation, and playfulness in the juvenile rat.Developmental cognitive neuroscience · 2011Article
- Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? : Adolescent Anhedonia and Posttraumatic Disorders.Current topics in behavioral neurosciencesArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Juvenile Fischer 344 rats are known to be less playful than other inbred strains, although the neurobiological substrate(s) responsible for this phenotype is uncertain. In the present study, Fischer 344 rats were compared to the commonly used outbred Sprague-Dawley strain on several behavioral and physiological parameters in order to ascertain whether the lack of play may be related to compromised activity of brain dopamine (DA) systems. As expected, Fischer 344 rats were far less playful than Sprague-Dawley rats, with Fischer 344 rats less likely to initiate playful contacts with a playful partner and less likely to respond playfully to these contacts. We also found that Fischer 344 rats showed less of a startle response and greater pre-pulse inhibition (PPI), especially at higher pre-pulse intensities. The increase in PPI seen in the Fischer 344 rat could be due to reduced DA modulation of sensorimotor gating and neurochemical measures were consistent with Fischer 344 rats releasing less DA than Sprague-Dawley rats. Fast scan cyclic voltammetry (FSCV) revealed Fischer 344 rats had less evoked DA release in dorsal and ventral striatal brain slices and high-performance liquid chromatography revealed Fischer 344 rats to have less DA turnover in the striatum and prefrontal cortex. We also found DA-dependent forms of cortical plasticity were deficient in the striatum and prefrontal cortex of the Fischer 344 rat. Taken together, these data indicate that deficits in play and enhanced PPI of Fischer 344 rats may be due to reduced DA modulation of corticostriatal and mesolimbic/mesocortical circuits critical to the execution of these behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.