Evidence map›Paper›PMID 21334966›Full record

ReviewCurrent opinion in microbiology2011

Regulation of gene expression by reiterative transcription.

Charles L Turnbough

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Structural and mechanistic basis of reiterative transcription initiation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Review
  5. Article
  6. Regulation of Bacterial Gene Expression by Transcription Attenuation.Microbiology and molecular biology reviews : MMBR · 2019
    Review
  7. Review
  8. Article
  9. X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Charles L TurnboughDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA. chuckt@uab.edu
University of Alabama at Birmingham · US

Funding

Bacterial gene regulation by the NTP substrates of transcription initiationR01GM094466 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TURNBOUGH, CHARLES LEE · 2010 to 2013
$1.1M
REGULATION OF PYRIMIDINE GENE EXPRESSION IN BACTERIAR01GM029466 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TURNBOUGH, CHARLES L. · 1985 to 2001
$604k
NIGMS NIH HHS GM29466NIGMS NIH HHS GM94466NIGMS NIH HHS R01 GM029466NIGMS NIH HHS R01 GM094466
6 · The paper itself

Abstract

Gene regulation involves many different types of transcription control mechanisms, including mechanisms based on reiterative transcription in which nucleotides are repetitively added to the 3' end of a nascent transcript due to upstream transcript slippage. In these mechanisms, reiterative transcription is typically modulated by interactions between RNA polymerase and its nucleoside triphosphate substrates without the involvement of regulatory proteins. This review describes the current state of knowledge of gene regulation involving reiterative transcription. It focuses on the methods by which reiterative transcription is controlled and emphasizes the different fates of transcripts produced by this reaction. The review also includes a discussion of possible new and fundamentally different mechanisms of gene regulation that rely on conditional reiterative transcription.

Indexed as

Gene Expression Regulation, BacterialTranscription, GeneticBacillus subtilisDNA-Directed RNA PolymerasesEscherichia coliModels, BiologicalNucleotidesRNA, MessengerDNA-Directed RNA PolymerasesNucleotidesRNA, Messenger

Identifiers

PMID21334966
PMCPMC3078970
OpenAlexW2017049218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.