ArticleJournal of the American Academy of Child and Adolescent Psychiatry2011
Mapping cortical morphology in youth with velocardiofacial (22q11.2 deletion) syndrome.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Longitudinal perspectives on the psychosis spectrum in 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2018Review
- Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis.Journal of child psychology and psychiatry, and allied disciplines · 2017Article
- The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety.Journal of psychiatry & neuroscience : JPN · 2016Article
- Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia.Translational psychiatry · 2016Article
- Altered Brain Structure-Function Relationships Underlie Executive Dysfunction in 22q11.2 Deletion Syndrome.Molecular neuropsychiatry · 2015Article
- A comparison of FreeSurfer-generated data with and without manual intervention.Frontiers in neuroscience · 2015Article
- Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion.Molecular psychiatry · 2014Article
- A longitudinal examination of the psychoeducational, neurocognitive, and psychiatric functioning in children with 22q11.2 deletion syndrome.Research in developmental disabilities · 2013Article
- 22q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basis.Neuropsychiatric disease and treatment · 2013Review
- Structural abnormalities in cortical volume, thickness, and surface area in 22q11.2 microdeletion syndrome: Relationship with psychotic symptoms.NeuroImage. Clinical · 2013Article
- Cortical gyrification in velo-cardio-facial (22q11.2 deletion) syndrome: a longitudinal study.Schizophrenia research · 2012Article
- Anxiety Disorders and Perceptual Disturbances in Adolescents with 22q11.2 Deletion Syndrome Treated with SSRI: A Case Series.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2011Article
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9 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveVelocardiofacial syndrome (VCFS; 22q11.2 deletion syndrome) represents one of the highest known risk factors for schizophrenia. Insofar as up to 30% of individuals with this genetic disorder develop schizophrenia, VCFS constitutes a unique, etiologically homogeneous model for understanding the pathogenesis of schizophrenia.
methodUsing a longitudinal, case-control design, anatomic magnetic resonance images were acquired to investigate cross-sectional and longitudinal alterations in surface cortical morphology in a cohort of adolescents with VCFS and age-matched typical controls. All participants were scanned at two time points.
resultsCompared with controls, youth with VCFS exhibited alterations in inferior frontal, dorsal frontal, occipital, and cerebellar brain regions at both time points. Little change was observed over time in surface morphology of either study group. However, within the VCFS group only, worsening psychosocial functioning over time was associated with time 2 surface contractions in left middle and inferior temporal gyri. Further, prodromal symptoms at time 2 were associated with surface contractions in the left and right orbitofrontal, temporal, and cerebellar regions and surface protrusions of the supramarginal gyrus.
conclusionsThese findings advance the understanding of cortical disturbances in VCFS that produce vulnerability for psychosis in this high-risk population.
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