ArticleNeurochemistry international2011
Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema.
Article in Neurochemistry international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Role of A-Kinase Anchoring Protein 12 in the Central Nervous System.Journal of clinical neurology (Seoul, Korea) · 2023Review
- Angiogenesis after ischemic stroke.Acta pharmacologica Sinica · 2023Review
- New insights into circRNA and its mechanisms in angiogenesis regulation in ischemic stroke: a biomarker and therapeutic target.Molecular biology reports · 2023Review
- GLP-1R Agonist Exendin-4 Protects Against Hemorrhagic Transformation Induced by rtPA After Ischemic Stroke via the Wnt/β-Catenin Signaling Pathway.Molecular neurobiology · 2022Article
- AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke.International journal of molecular sciences · 2020Article
- DHA Attenuates Hypoxia/Reoxygenation Injury by Activating SSeCKS in Human Cerebrovascular Pericytes.Neurochemical research · 2020Article
- Elastin-Derived Peptide VGVAPG Affects Production and Secretion of Testosterone in Mouse Astrocyte In Vitro.Neurochemical research · 2020Article
- Plasma Levels, Temporal Trends and Clinical Associations between Biomarkers of Inflammation and Vascular Homeostasis after Pediatric Traumatic Brain Injury.Developmental neuroscience · 2019Article
- Roles of HIF-1α, VEGF, and NF-κB in Ischemic Preconditioning-Mediated Neuroprotection of Hippocampal CA1 Pyramidal Neurons Against a Subsequent Transient Cerebral Ischemia.Molecular neurobiology · 2017Article
- GSK-3β as a target for protection against transient cerebral ischemia.International journal of medical sciences · 2017Article
- GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats.Molecular neurobiology · 2016Article
- LRG1 promotes angiogenesis through upregulating the TGF‑β1 pathway in ischemic rat brain.Molecular medicine reports · 2016Article
- Neuroprotective effect of Cerebralcare Granule after cerebral ischemia/reperfusion injury.Neural regeneration research · 2016Article
- Progesterone Changes VEGF and BDNF Expression and Promotes Neurogenesis After Ischemic Stroke.Molecular neurobiology · 2016Article
- Vascular endothelial growth factor: an attractive target in the treatment of hypoxic/ischemic brain injury.Neural regeneration research · 2016Review
- Hemorrhagic Transformation after Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke: Mechanisms, Models, and Biomarkers.Molecular neurobiology · 2015Review
- Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice.Brain, behavior, and immunity · 2015Article
- PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice.Neurobiology of aging · 2015Article
- Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion.Neuroscience · 2014Article
- Electroacupuncture treatment improves neurological function associated with regulation of tight junction proteins in rats with cerebral ischemia reperfusion injury.Evidence-based complementary and alternative medicine : eCAM · 2014Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
A better understanding of the underlying mechanisms of angiogenesis and vascular permeability is necessary for the development of therapeutic strategies for ischemic injury. The purpose of this study was to examine the spatial and temporal expression of Src and Src-suppressed C kinase substrate (SSeCKS) in brain after middle cerebral artery occlusion (MCAO) and elucidate the relationships among Src, SSeCKS, and the key angiogenic factors present after stroke. Rats were subjected to either MCAO or sham operation. Reverse transcriptase-polymerase chain reaction and Western blotting results revealed that Src gradually increased starting as early as 2 h after MCAO and remained high for 1 day. In contrast, SSeCKS decreased after MCAO. Src expression correlated positively with that of vascular endothelial growth factor and angiopoietin-2, and negatively with that of SSeCKS, angiopoietin-1, and zonula occludens-1. However, SSeCKS had the reverse correlations. Changes in the expression of these factors correlated with the progress of angiogenesis and cerebral edema. Dynamic temporal changes in Src and SSeCKS expression may modulate angiogenesis and cerebral edema formation after focal cerebral ischemia.
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