Evidence map›Paper›PMID 21334194›Full record

ReviewCurrent opinion in neurobiology2011

Long-term plasticity at inhibitory synapses.

Pablo E Castillo, Chiayu Q Chiu, Reed C Carroll

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Octopamine instructs head direction plasticity.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Article
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  14. Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023
    Review
  15. Review
  16. CaFrontiers in cellular neuroscience · 2023
    Article
  17. Article
  18. Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  19. Review
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pablo E CastilloDominick P. Purpura, Department of Neuroscience, Albert Einstein College of Medicine, Kennedy Center, Room 703, Bronx, NY 10461, United States. pablo.castillo@einstein.yu.edu
Chiayu Q Chiu
Reed C Carroll

Funding

Presynaptic Forms of Long-Term Plasticity in the CNSR01DA017392 · NIDA · YESHIVA UNIVERSITY · PI CASTILLO, PABLO E · 2003 to 2019
$4.5M
NIDA NIH HHS R01 DA017392
6 · The paper itself

Abstract

Experience-dependent modifications of neural circuits and function are believed to heavily depend on changes in synaptic efficacy such as LTP/LTD. Hence, much effort has been devoted to elucidating the mechanisms underlying these forms of synaptic plasticity. Although most of this work has focused on excitatory synapses, it is now clear that diverse mechanisms of long-term inhibitory plasticity have evolved to provide additional flexibility to neural circuits. By changing the excitatory/inhibitory balance, GABAergic plasticity can regulate excitability, neural circuit function and ultimately, contribute to learning and memory, and neural circuit refinement. Here we discuss recent advancements in our understanding of the mechanisms and functional relevance of GABAergic inhibitory synaptic plasticity.

Indexed as

AnimalsHumansNeuronal PlasticitySynapses

Identifiers

PMID21334194
PMCPMC3092861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.