Evidence map›Paper›PMID 21334154›Full record

ArticleDiagnostic microbiology and infectious disease2011

Prevalence, persistence, and microbiology of Staphylococcus aureus nasal carriage among hemodialysis outpatients at a major New York Hospital.

Elizabeth L Alexander, Daniel J Morgan, Sandra Kesh, Scott A Weisenberg, Janice M Zaleskas, Anna Kaltsas, James M Chevalier, Jeffrey Silberzweig, Yolanda Barrón, Jose R Mediavilla and 2 more

Open access · greenAbstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Elizabeth L AlexanderDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Daniel J Morgan
Sandra Kesh
Scott A Weisenberg
Janice M Zaleskas
Anna Kaltsas
James M Chevalier
Jeffrey Silberzweig
Yolanda Barrón
Jose R Mediavilla
Barry N Kreiswirth
Kyu Y Rhee
Cornell University · USLahey Hospital and Medical Center · USThe Rogosin Institute · USUniversity of Maryland, Baltimore · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
T32: Pathogenesis of Infectious Diseases Training ProgramT32AI007613 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 1999 to 2026
$8.8M
Improving Patient Safety and Disease Management While on Contact IsolationK08HS018111 · AHRQ · UNIVERSITY OF MARYLAND BALTIMORE · PI MORGAN, DANIEL J · 2009 to 2013
$628k
AHRQ HHS K08 HS018111AHRQ HHS K08 HS18111-01NCRR NIH HHS UL1 RR024996NCRR NIH HHS UL1RR024996NIAID NIH HHS T32 AI 007613NIAID NIH HHS T32 AI007613
6 · The paper itself

Abstract

The study aimed to determine the natural history of Staphylococcus aureus nasal colonization in hemodialysis outpatients. Surveillance cultures were taken from patients presenting for hemodialysis or routine care to identify S. aureus nasal carriers. A prospective cohort study was performed to identify risks for persistent colonization. Detailed microbiologic and molecular studies of colonizing isolates were performed. Only 23/145 (15.9%) dialysis patients were persistently colonized, and only HIV-positive status was associated with persistence (P = 0.05). Prior hospitalization was the only risk factor for methicillin-resistant S. aureus carriage (OR 2.5, P = 0.03). In isolates from patients with ≤ 42 days of vancomycin exposure, vancomycin minimum bactericidal concentrations (MBCs) increased with duration of exposure. Among dialysis patients, S. aureus colonization was limited and transient; only HIV status was associated with persistence. Nevertheless, duration of vancomycin exposure was associated with increasing vancomycin MBCs. Vancomycin exposure in S. aureus carriers may be involved in increasing resistance.

Indexed as

AdultAgedAged, 80 and overAnti-Bacterial AgentsCarrier StateCohort StudiesFemaleHemodialysis Units, HospitalHIV InfectionsHumansMaleMiddle AgedNasal MucosaNew YorkOutpatientsProspective StudiesAnti-Bacterial AgentsVancomycin

Identifiers

PMID21334154
PMCPMC3534839
OpenAlexW2111407037

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.