ReviewGastroenterology clinics of North America2011
The role of genetics in IBS.
Review in Gastroenterology clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Map the prevalence of irritable bowel syndrome across China: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Research on functional constipation with anxiety or depression: a bibliometric analysis.Frontiers in psychiatry · 2025Pooled it
- Duloxetine as a gut-brain axis modulator in irritable bowel syndrome: neuroimmune, microbiota, and pharmacogenomic perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Prevalence of irritable bowel syndrome and its association with lifestyle factors among medical students in Jordan: a cross-sectional survey.Scientific reports · 2026Article
- Unraveling the Pathophysiology of Irritable Bowel Syndrome: Mechanisms and Insights.International journal of molecular sciences · 2025Review
- Linking IgE-mediated CMPA to functional gastrointestinal disorders.European journal of pediatrics · 2025Article
- Familial coaggregation and shared familiality of functional and internalizing disorders in the Lifelines cohort.Psychological medicine · 2025Article
- Irritable Bowel Syndrome: A Hallmark of Psychological Distress in Women?Life (Basel, Switzerland) · 2025Review
- Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue.Translational psychiatry · 2024Article
- Genetic Variations in TrkB.T1 Isoform and Their Association With Somatic and Psychological Symptoms in Individuals With IBS.The journal of pain · 2024Article
- Food Intolerances, Food Allergies and IBS: Lights and Shadows.Nutrients · 2024Review
- Review
- Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review.Journal of clinical medicine · 2023Review
- Review
- Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies.Nature reviews. Gastroenterology & hepatology · 2022Review
- Gut Microbiota Manipulation in Irritable Bowel Syndrome.Microorganisms · 2022Review
- Targeted therapy of irritable bowel syndrome with anti-inflammatory cytokines.Clinical journal of gastroenterology · 2022Review
- Sex and Gender Differences in Overlap Syndrome of Functional Gastrointestinal Disorder and Effect of Genetic Polymorphisms in South Korea: A Long-term Follow-up Study.Journal of neurogastroenterology and motility · 2022Article
- Article
- Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.Nature genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.