ArticleRespiratory physiology & neurobiology2011
Serotonin transporter null male mouse pups have lower ventilation in air and 5% CO2 at postnatal ages P15 and P25.
Article in Respiratory physiology & neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Exaggerated postnatal surge of orexin neurons and the effects of elimination of excess orexin on blood pressure and exaggerated chemoreflex in spontaneously hypertensive rats.Frontiers in physiology · 2024Article
- Medullary serotonin neurons are CO2 sensitive in situ.Journal of neurophysiology · 2013Article
- The physiological determinants of sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
- Soluble guanylate cyclase modulates alveolarization in the newborn lung.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Article
- Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous.Forensic science, medicine, and pathology · 2012Review
- Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis.Journal of chemical neuroanatomy · 2011Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In Wild Type (WT) and serotonin transporter (5HTT) null mice, we studied oxygen consumption, ventilation and heart rate in air and 5% CO(2) at postnatal (P) days P5, P15, and P25 using either a head-out (younger mice) or whole body plethysmograph (older mice). Body weight and temperature did not differ between the groups. Oxygen consumption differed significantly only in females at P15 when it was reduced in 5HTT nulls (P<0.01). Heart rate similarly differed only in female 5HTT nulls at P15 being decreased in both air and CO(2) (P<0.01). Ventilation in air and 5% CO(2) was significant reduced via an effect on tidal volume at P15 (P<0.02) and P25 (P<0.05) but only in males. Ventilation in air and 5% CO(2) was greater in 5HTT null females at P25. We conclude that the gender specific effect (male predominant) on the CO(2) response reported in 5HTT null adult mice (Li and Nattie, 2008, J. Physiol. 586.9, 2321-2329, 2008) appears to have origins in early postnatal life (P15) when ventilation in both air and 5% CO(2) is reduced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.