ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2011
Corticospinal tract integrity correlates with knee extensor weakness in chronic stroke survivors.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03122821 (Effect of Transcranial Stimulation Augmented With Mental Imagery in Upper Limb Stroke Rehabilitation), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Transcranial Stimulation Augmented With Mental Imagery in Upper Limb Stroke Rehabilitation: A Randomized Controlled Trial
Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Effect of knee angle on quadriceps strength and activation after anterior cruciate ligament reconstruction.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Advancing Stroke Recovery Through Operant Conditioning of Corticomuscular Coherence.Restorative neurology and neuroscience · 2026Review
- Improving interlimb coordination and paretic limb use after stroke using a novel robotic split-crank pedaling device: a cross-sectional study.Journal of neuroengineering and rehabilitation · 2026Article
- The relationship between corticospinal tract and the affected lower limb function and walking ability in subacute stroke patients: a preliminary study.Journal of physical therapy science · 2026Article
- Subclinical knee extensor weakness predicts gait and balance impairment in degenerative cervical myelopathy.GeroScience · 2025Observational
- Age-related differences in agility are related to both muscle strength and corticospinal tract function.Physiological reports · 2025Article
- Effects of non-invasive cervical spinal cord neuromodulation by trans-spinal electrical stimulation on cortico-muscular descending patterns in upper extremity of chronic stroke.Frontiers in bioengineering and biotechnology · 2024Article
- Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles.Frontiers in neuroscience · 2023Article
- Upper Limbs Muscle Co-contraction Changes Correlated With the Impairment of the Corticospinal Tract in Stroke Survivors: Preliminary Evidence From Electromyography and Motor-Evoked Potential.Frontiers in neuroscience · 2022Article
- The Strength of the Corticospinal Tract Not the Reticulospinal Tract Determines Upper-Limb Impairment Level and Capacity for Skill-Acquisition in the Sub-Acute Post-Stroke Period.Neurorehabilitation and neural repair · 2021Article
- Employment Resources for People with Parkinson's Disease: A Resource Review and Needs Assessment.Journal of occupational rehabilitation · 2021Article
- Axonal remodeling of the corticospinal tract during neurological recovery after stroke.Neural regeneration research · 2021Review
- Functional Resistance Training to Improve Knee Strength and Function After Acute Anterior Cruciate Ligament Reconstruction: A Case Study.Sports health · 2021Article
- Upper and Lower Limb Motor Function Correlates with Ipsilesional Corticospinal Tract and Red Nucleus Structural Integrity in Chronic Stroke: A Cross-Sectional, ROI-Based MRI Study.Behavioural neurology · 2021Article
- Comparison of ground reaction force during gait between the nonparetic side in hemiparetic patients and the dominant side in healthy subjects.Journal of exercise rehabilitation · 2020Article
- Individualized Responses to Ipsilesional High-Frequency and Contralesional Low-Frequency rTMS in Chronic Stroke: A Pilot Study to Support the Individualization of Neuromodulation for Rehabilitation.Frontiers in human neuroscience · 2020Article
- A Unifying Pathophysiological Account for Post-stroke Spasticity and Disordered Motor Control.Frontiers in neurology · 2019Article
- Effect of bilateral lower limb strengthening exercise on balance and walking in hemiparetic patients after stroke: a randomized controlled trial.Journal of physical therapy science · 2018Article
- Lower Extremity Motor Impairments in Ambulatory Chronic Hemiparetic Stroke: Evidence for Lower Extremity Weakness and Abnormal Muscle and Joint Torque Coupling Patterns.Neurorehabilitation and neural repair · 2017Article
- Spasticity, Motor Recovery, and Neural Plasticity after Stroke.Frontiers in neurology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMuscle weakness develops rapidly after stroke, adversely affecting motor performance, and contributing to reduced functional ability. While the contributions of structural and functional alterations in skeletal muscle to post-stroke weakness have been well described, the relationship between motor pathway integrity, measured using both radiological and electrophysiological techniques, and post-stroke muscle weakness is not clear. This study sought to determine the role of corticospinal tract (CST) integrity on knee extensor weakness in chronic stroke survivors.
methodsKnee extensor strength and activation testing were performed at 90° of knee flexion using an interpolated triplet technique. CST integrity was evaluated using data obtained from Diffusion Tensor Imaging and transcranial magnetic stimulation.
resultsRecordings in nine stroke subjects indicated substantial knee extensor weakness and activation deficits in the paretic legs of the stroke survivors. Regression analysis revealed that asymmetry in CST integrity was strongly related to between-leg differences in knee strength.
conclusionsThe results of this study suggest a strong link between CST integrity and lower extremity strength, and add to the growing evidence of substantial knee extensor weakness and activation impairments in stroke survivors. SIGNIFICANCE: The findings from this study further our understanding of the anatomical and neurophysiological contributions to motor impairments after stroke, which may benefit clinicians and researchers in the field of stroke rehabilitation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.