ArticleCurrent biology : CB2011
Plant stem cell signaling involves ligand-dependent trafficking of the CLAVATA1 receptor kinase.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Regulatory layers of robustness of CLAVATA-WUSCHEL feedback system in stem cell homeostasis.Frontiers in plant science · 2026Review
- Research Progress of CLE and Its Prospects in Woody Plants.Plants (Basel, Switzerland) · 2025Review
- A novel LRR receptor-like kinase BRAK reciprocally phosphorylates PSKR1 to enhance growth and defense in tomato.The EMBO journal · 2024Article
- Macromolecular tool box to elucidate CLAVATA3/EMBRYO SURROUNDING REGION-RELATED-RLK binding, signaling, and downstream effects.Journal of experimental botany · 2024Article
- UV-B Radiation Disrupts Membrane Lipid Organization and Suppresses Protein Mobility of GmNARK inPlants (Basel, Switzerland) · 2024Article
- A novel toolbox to record CLE peptide signaling.Frontiers in plant science · 2024Article
- Functional Modules in the Meristems: "Tinkering" in Action.Plants (Basel, Switzerland) · 2023Review
- Asymmetric Evolution of Protein Domains in the Leucine-Rich Repeat Receptor-Like Kinase Family of Plant Signaling Proteins.Molecular biology and evolution · 2023Article
- Stem Cells: Engines of Plant Growth and Development.International journal of molecular sciences · 2023Review
- TPLATE complex-dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance.EMBO reports · 2023Article
- A network of CLAVATA receptors buffers auxin-dependent meristem maintenance.Nature plants · 2023Article
- Phosphorylation-dependent routing of RLP44 towards brassinosteroid or phytosulfokine signalling.Journal of cell science · 2021Article
- Control ofeLife · 2021Article
- BdERECTA controls vasculature patterning and phloem-xylem organization in Brachypodium distachyon.BMC plant biology · 2021Article
- The manifold actions of signaling peptides on subcellular dynamics of a receptor specify stomatal cell fate.eLife · 2020Article
- Regulation of reactive oxygen species during plant immunity through phosphorylation and ubiquitination of RBOHD.Nature communications · 2020Article
- Peptide-Receptor Signaling Controls Lateral Root Development.Plant physiology · 2020Review
- Paired Receptor and Coreceptor Kinases Perceive Extracellular Signals to Control Plant Development.Plant physiology · 2020Review
- The Role of Plasmodesmata-Associated Receptor in Plant Development and Environmental Response.Plants (Basel, Switzerland) · 2020Review
- POLTERGEIST and POLTERGEIST-LIKE1 are essential for the maintenance of post-embryonic shoot and root apical meristems as revealed by a partial loss-of-function mutant allele of pll1 in Arabidopsis.Genes & genomics · 2020Article
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5 authors.
Funding
Abstract
backgroundCell numbers in above-ground meristems of plants are thought to be maintained by a feedback loop driven by perception of the glycopeptide ligand CLAVATA3 (CLV3) by the CLAVATA1 (CLV1) receptor kinase and the CLV2/CORYNE (CRN) receptor-like complex. CLV3 produced in the stem cells at the meristem apex limits the expression level of the stem cell-promoting homeodomain protein WUSCHEL (WUS) in the cells beneath, where CLV1 and WUS RNA are localized. WUS downregulation nonautonomously reduces stem cell proliferation. Overexpression of CLV3 eliminates the stem cells, causing meristem termination, and loss of CLV3 function allows meristem overproliferation. There are many questions regarding the CLV3/CLV1 interaction, including where in the meristem it occurs, how it is regulated, and how it is that a large range of CLV3 concentrations gives no meristem size phenotype.
resultsHere we use genetics and live imaging to examine the cell biology of CLV1 in Arabidopsis meristematic tissue. We demonstrate that plasma membrane-localized CLV1 is reduced in concentration by CLV3, which causes trafficking of CLV1 to lytic vacuoles. We find that changes in CLV2 activity have no detectable effects on CLV1 levels. We also find that CLV3 appears to diffuse broadly in meristems, contrary to a recent sequestration model.
conclusionsThis study provides a new model for CLV1 function in plant stem cell maintenance and suggests that downregulation of plasma membrane-localized CLV1 by its CLV3 ligand can account for the buffering of CLV3 signaling in the maintenance of stem cell pools in plants.
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