Evidence map›Paper›PMID 21333525›Full record

ReviewCurrent opinion in neurobiology2011

Neuromodulatory control of striatal plasticity and behavior.

Talia N Lerner, Anatol C Kreitzer

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Talia N LernerGladstone Institute of Neurological Disease, San Francisco, CA, USA.
Anatol C Kreitzer
University of California, San Francisco · US

Funding

Neuron- and Circuit-Specific Mechanisms and Adaptations Regulating Striatal FunctR01NS064984 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI KREITZER, ANATOL · 2009 to 2022
$5.1M
NINDS NIH HHS R01 NS064984
6 · The paper itself

Abstract

Excitatory synapses onto projection neurons in the striatum, the input nucleus of the basal ganglia, play a key role in regulating basal ganglia circuit function and are a major site of long-term synaptic plasticity. Here, we review the mechanisms and regulation of both long-term potentiation and long-term depression at these synapses. In particular, we highlight the role that neuromodulators play in determining the strength and direction of plasticity, which ultimately shapes the balance of activity in basal ganglia circuits and regulates motor behavior.

Indexed as

AnimalsBehaviorCorpus StriatumHumansNeuronal PlasticityPsychomotor Performance

Identifiers

PMID21333525
PMCPMC3092792
OpenAlexW2015634638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.