ArticleJournal of reproductive immunology2011
Toll-like receptors and signalling in spermatogenesis and testicular responses to inflammation--a perspective.
Article in Journal of reproductive immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 91 citations in OpenAlex.
- Therapeutic Ultrasound Versus Levofloxacin in Lipopolysaccharide-Induced Orchitis: Comparative Effects on Testicular Inflammation and Tissue Recovery in Rats.Iranian journal of pathology · 2026Article
- Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.Seminars in immunopathology · 2026Review
- Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal-Fetal Tolerance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Chronic prostatitis and male infertility: association mechanism and research progress.World journal of urology · 2025Review
- Insecticides and testicular health: mechanisms of injury and protective natural products.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The beneficial effect of propolis during an eight-weeks of resistance training on TNF-α and IL-6 genes expression in the kidney tissue of female Wistar rats undergoing testosterone enanthate consumption.Current research in physiology · 2025Article
- Testicular immunity.Molecular aspects of medicine · 2024Review
- Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis.Histochemistry and cell biology · 2024Article
- Article
- Dysbiosis of Gut Microbiome Aggravated Male Infertility in Captivity of Plateau Pika.Biomolecules · 2024Article
- Pro-inflammatory cytokines and reproductive hormone responses in bucks post-challenge with Mannheimia haemolytica A2 and its outer membrane protein.Tropical animal health and production · 2023Article
- FSH promotes immature porcine Sertoli cell proliferation by activating the CCR7/Ras-ERK signaling axis.Reproduction (Cambridge, England) · 2023Article
- Review
- Protective role of melatonin against testicular damage caused by polymicrobial sepsis in adult rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Article
- Bibliometric and visual analysis of blood-testis barrier research.Frontiers in pharmacology · 2022Article
- LPS-Induced Systemic Inflammation Caused mPOA-FSH/LH Disturbance and Impaired Testicular Function.Frontiers in endocrinology · 2022Article
- Chronic alcohol-induced dysbiosis of the gut microbiota and gut metabolites impairs sperm quality in mice.Frontiers in microbiology · 2022Article
- Oxidant-Sensitive Inflammatory Pathways and Male Reproductive Functions.Advances in experimental medicine and biology · 2022Article
- Integrative analyses of potential biomarkers and pathways for non-obstructive azoospermia.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is self-evident that infection and inflammation in the reproductive tract can inhibit male fertility, but the observation that fertility may also be compromised by systemic inflammation and disease is more difficult to explain. Recent studies implicating microbial pattern-recognition receptors, such as the Toll-like receptors (TLRs), as well as inflammatory cytokines and their signalling pathways, in testicular function have cast new light on this mysterious link between infection/inflammation and testicular dysfunction. It is increasingly evident that signalling pathways normally involved in controlling inflammation play fundamental roles in regulating Sertoli cell activity and responses to reproductive hormones, in addition to promoting immune responses within the testis. Many of the negative effects of inflammation on spermatogenesis may be attributed to elevated production of inflammation-related gene products within the circulation and the testis, which subsequently exert disruptive effects on spermatogenic cell development and survival, as well as the ability of the Sertoli cells to provide support for spermatogenesis. These interactions have important implications for testicular dysfunction and disease, and may eventually provide new opportunities for therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.