ArticleThe Journal of allergy and clinical immunology2011
Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study).
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00114881 (Urban Environment and Childhood Asthma), which is not on this map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urban Environment and Childhood Asthma (URECA)
Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- Relation between stress and cytokine responses in inner-city mothers.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015Trial
- Umbilical Cord Blood Biomarkers for Early Risk Stratification of Childhood Asthma and Atopic Dermatitis: A Developmental and Critical Appraisal.Journal of asthma and allergy · 2026Review
- The fetal exposome: cellular and epigenetic programming of neonatal immune function.Frontiers in immunology · 2026Review
- Protocol design for the ACTIVATE clinical trial: Exposure to vaginal microbiome in cesarean-delivered infants at high risk for allergies.The journal of allergy and clinical immunology. Global · 2025Article
- Influence of Biological Sex and Congenital Iron Deficiency on Neonatal Cytokine Responses.Nutrients · 2024Article
- Article
- Cytokine production by newborns: influence of sex and season of birth.Pediatric research · 2023Article
- Duration of exposure to epidural anesthesia at delivery, DNA methylation in umbilical cord blood and their association with offspring asthma in Non-Hispanic Black women.Environmental epigenetics · 2023Article
- Maternal stress and depression are associated with respiratory phenotypes in urban children.The Journal of allergy and clinical immunology · 2021Article
- Air Pollution, Neonatal Immune Responses, and Potential Joint Effects of Maternal Depression.International journal of environmental research and public health · 2021Article
- The early life education of the immune system: Moms, microbes and (missed) opportunities.Gut microbes · 2020Review
- Prenatal Maternal Depression and Neonatal Immune Responses.Psychosomatic medicine · 2019Article
- Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions".The Journal of allergy and clinical immunology · 2019Article
- Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment.European journal of immunology · 2018Review
- Prenatal maternal depression related to allergic rhinoconjunctivitis in the first 5 years of life in children of the EDEN mother-child cohort study.Allergy & rhinology (Providence, R.I.) · 2017Article
- Cockroach allergen exposure and plasma cytokines among children in a tropical environment.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
- Prenatal Maternal Distress and Allergic Diseases in Offspring: Review of Evidence and Possible Pathways.Allergy, asthma & immunology research · 2017Review
- Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families.American journal of respiratory and critical care medicine · 2017Article
- Prenatal Maternal Stress and the Risk of Lifetime Wheeze in Young Offspring: An Examination by Stressor and Maternal Ethnicity.Journal of immigrant and minority health · 2016Article
- Prenatal and postnatal stress and wheeze in Mexican children: Sex-specific differences.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundThe Urban Environment and Childhood Asthma study was established to investigate the immunologic and environmental causes of asthma in inner-city children.
objectiveWe sought to evaluate potential atopic outcomes in the first 12 months and their relationships to environmental exposures and immune development.
methodsA birth cohort of 560 children with at least 1 parent with allergy or asthma was established in Baltimore, Boston, New York, and St Louis. Wheezing is assessed every 3 months, allergen-specific IgE yearly, and mononuclear cell cytokine responses at birth and yearly; environmental assessments include dust allergen and endotoxin, maternal stress, and indoor nicotine and nitrogen dioxide levels.
resultsKey outcomes in the first year include wheeze in 49%, 2 or more episodes of wheeze in 23%, eczema in 30%, and detectable IgE to milk, egg, and/or peanut in 32% and to cockroach in 4%. Household dust revealed levels of greater than 2 μg/g to cockroach in 40%, mite in 19%, cat in 25%, and mouse in 29%, and 66% of homes housed at least 1 smoker. Positive associations were detected between multiple wheeze and cotinine levels, maternal stress, and maternal depression, whereas cytokine responses to a variety of innate, adaptive, and mitogenic stimuli were inversely related to eczema.
conclusionsThis high-risk cohort of inner-city infants is exhibiting high rates of wheeze, eczema, and allergic sensitization. Low cytokine responses at birth might be a risk factor for eczema, whereas a variety of adverse environmental exposures contribute to the risk of wheezing in infancy. These findings provide evidence of specificity in the interactions between immune development, environmental exposures, and the development of early features that might predict future asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.