ArticleBiomacromolecules2011
Fibroblast/fibrocyte: surface interaction dictates tissue reactions to micropillar implants.
Article in Biomacromolecules, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Microtopographical patterns promote different responses in fibroblasts and Schwann cells: A possible feature for neural implants.Journal of biomedical materials research. Part A · 2021Article
- Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats.Acta cirurgica brasileira · 2020Article
- Domesticating the foreign body response: Recent advances and applications.Advanced drug delivery reviews · 2019Review
- A contact lens promising for non-invasive continuous intraocular pressure monitoring.RSC advances · 2019Article
- Biomaterials: Foreign Bodies or Tuners for the Immune Response?International journal of molecular sciences · 2019Review
- Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks.Advanced biosystems · 2017Article
- One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing.Sensors (Basel, Switzerland) · 2016Article
- On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing.Biomicrofluidics · 2015Article
- Innate Immunity and Biomaterials at the Nexus: Friends or Foes.BioMed research international · 2015Review
- Characterisation of the cellular infiltrate in the foreign body granuloma of textile meshes with its impact on collagen deposition.Hernia : the journal of hernias and abdominal wall surgery · 2014Article
- A computational model of fibroblast and macrophage spatial/temporal dynamics in foreign body reactions.Journal of immunological methods · 2013Article
- Linear fibroblast alignment on sinusoidal wave micropatterns.Colloids and surfaces. B, Biointerfaces · 2013Article
- Hemocompatibility of polymeric nanostructured surfaces.Journal of biomaterials science. Polymer edition · 2013Article
- Noninvasive assessment of localized inflammatory responses.Free radical biology & medicine · 2012Article
- Real-time detection of implant-associated neutrophil responses using a formyl peptide receptor-targeting NIR nanoprobe.International journal of nanomedicine · 2012Article
- Real time monitoring of biomaterial-mediated inflammatory responses via macrophage-targeting NIR nanoprobes.Biomaterials · 2011Article
- The pivotal role of fibrocytes and mast cells in mediating fibrotic reactions to biomaterials.Biomaterials · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Micropillar technology has shown great promise for medical implants or sensors in recent years. To study the influence of surface topography on cellular responses, polydimethylsiloxane (PDMS) micropillar arrays with pillar spacing (20-70 μm) and height (14-25 μm) have been fabricated. The influence of micropillar arrays on cellular behavior was tested both in vitro and in vivo. Interestingly, in vitro, we observe a distinct response for 3T3 fibroblasts and RAW 264.7 macrophages to the topographical cues tested. Attachment and proliferation of fibroblasts was substantially enhanced by increasing pillar height, whereas macrophage adherence is significantly diminished by reduced pillar spacing. When implanted in the subcutaneous cavity of BALB/c mice for 14 days, we find a prevailing trend with capsule cell density and capsule thickness increasing, as both pillar height and spacing rise. Collagen deposition and neoangiogenesis, two pivotal factors in granulation tissue maturation, are also observed to have a stronger response to the increase in both pillar height and spacing. In contradiction to our original hypothesis, we observed that fibroblasts rather than macrophages are a key contributor to the in vivo outcome of micropillar arrays. Investigation into fibroblast activation, however, revealed that recruited fibrocytes, rather than resident fibroblasts, correspond to the in vivo outcome. The results from this work support the critical and often overlooked role of fibrocytes in tissue response to biomaterial implants with varying topography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.