ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2011
Springs, clutches and motors: driving forward kinetochore mechanism by modelling.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Bayesian data driven modelling of kinetochore dynamics: Space-time organisation of the human metaphase plate.PLoS computational biology · 2026Article
- Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch.Science advances · 2025Article
- Attenuated Chromosome Oscillation as a Cause of Chromosomal Instability in Cancer Cells.Cancers · 2021Review
- Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I.Open biology · 2021Article
- Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling.eLife · 2020Article
- A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition.Cell reports · 2016Article
- NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force.Nature communications · 2016Article
- Inferring the Forces Controlling Metaphase Kinetochore Oscillations by Reverse Engineering System Dynamics.PLoS computational biology · 2015Article
- Fission yeast kinesin-8 controls chromosome congression independently of oscillations.Journal of cell science · 2015Article
- Modelling chromosome dynamics in mitosis: a historical perspective on models of metaphase and anaphase in eukaryotic cells.Interface focus · 2014Review
- A mathematical model of force generation by flexible kinetochore-microtubule attachments.Biophysical journal · 2014Article
- Dynamic bonds and polar ejection force distribution explain kinetochore oscillations in PtK1 cells.The Journal of cell biology · 2013Article
- Biophysics of mitosis.Quarterly reviews of biophysics · 2012Review
- The coupling between sister kinetochore directional instability and oscillations in centromere stretch in metaphase PtK1 cells.Molecular biology of the cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a mechanical system, the kinetochore can be viewed as a set of interacting springs, clutches and motors; the problem of kinetochore mechanism is now one of understanding how these functional modules assemble, disassemble and interact with one another to give rise to the emergent properties of the system. The sheer complexity of the kinetochore system points to a future requirement for data-driven mathematical modelling and statistical analysis based on quantitative empirical measurement of sister kinetochore trajectories. Here, we review existing models of chromosome motion in the context of recent advances in our understanding of kinetochore molecular biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.