ArticleJapanese journal of ophthalmology2011
Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost.
Article in Japanese journal of ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 124 citations in OpenAlex.
- Article
- Oculoplastic Challenges in Patients with Glaucoma.Turkish journal of ophthalmology · 2025Review
- Severe Microbial Keratitis Secondary to Prostaglandin-Associated Periorbitopathy.Case reports in ophthalmological medicine · 2025Article
- New Findings in Prominent Lower Eyelid Fat Pads Possibly Contributing to Their Etiology: Two Prospective Studies.Plastic and reconstructive surgery. Global open · 2024Article
- From Eye Care to Hair Growth: Bimatoprost.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Prescribing trends of glaucoma medication in Korea from 2007 to 2020: A nationwide population-based study.PloS one · 2024Article
- Effect of retrobulbar prostaglandin analog injection on orbital fat in rats.International ophthalmology · 2023Article
- Prostaglandin F2α Regulates Adipogenesis by Modulating Extracellular Signal-Regulated Kinase Signaling in Graves' Ophthalmopathy.International journal of molecular sciences · 2023Article
- Improvement of Prostaglandin-Associated Periorbitopathy after Discontinuing Treatment.Turkish journal of ophthalmology · 2023Article
- Ocular surface disease: a known yet overlooked side effect of topical glaucoma therapy.Frontiers in toxicology · 2023Review
- Cytotoxicity, Mitochondrial Functionality, and Redox Status of Human Conjunctival Cells after Short and Chronic Exposure to Preservative-Free Bimatoprost 0.03% and 0.01%: An In Vitro Comparative Study.International journal of molecular sciences · 2022Article
- Brimonidine Modulates the ROCK1 Signaling Effects on Adipogenic Differentiation in 2D and 3D 3T3-L1 Cells.Bioengineering (Basel, Switzerland) · 2022Article
- Shortening of interpupillary distance after topical prostaglandin analog eye drop application in an ophthalmic surgeon: A case report.American journal of ophthalmology case reports · 2022Article
- Recovery of deepening of the upper eyelid sulcus after switching from prostaglandin FP receptor agonists to EP2 receptor agonist: a 3-month prospective analysis.Japanese journal of ophthalmology · 2021Observational
- Prostanoid receptor agonists for glaucoma treatment.Japanese journal of ophthalmology · 2021Review
- Prostaglandin F2α agonists induced enhancement in collagen1 expression is involved in the pathogenesis of the deepening of upper eyelid sulcus.Scientific reports · 2021Article
- Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells.Scientific reports · 2020Article
- Article
- Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts.Investigative ophthalmology & visual science · 2020Article
- Prostaglandin F2α agonist-induced suppression of 3T3-L1 cell adipogenesis affects spatial formation of extra-cellular matrix.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo confirm the possible mechanism by which topical prostaglandin antiglaucoma drugs cause a deep superior sulcus.
methodsAmong patients who used bimatoprost (Lumigan), latanoprost (Xalatan), or travoprost (Travatan) and who developed a deep upper lid sulcus, 18 eyes of 11 patients (mean age, 58.2 ± 8.9 years) were studied. Seven patients were binocular users of one of the eye drops and four were monocular users. Preaponeurotic orbital fat was obtained, and the mean adipocyte density compared.
resultsIn the four monocular users, mean adipocyte density of treated eyes was 1758.21 ± 158.15 cells/mm(2), and that of untreated eyes was 1258.73 ± 127.54 cells/mm(2). This difference was statistically significant (P = 0.04), suggesting that the adipocytes were atrophied in the treated eyes. The mean adipocyte density of the bimatoprost group was 2073.35 ± 184.89 cells/mm(2), that of the travoprost group was 1623.46 ± 218.99 cells/mm(2), and that of the latanoprost group was 1468.20 ± 113.44 cells/mm(2). The densities of the bimatoprost and travoprost groups, but not of the latanoprost group (P = 0.75), were significantly different from that of the untreated group (P < 0.001).
conclusionsFat atrophy can be considered a mechanism of upper eyelid sulcus deepening in patients using topical prostaglandin analogs.
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