ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2011
Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Middle meningeal artery embolization for migraine: A review.Surgical neurology international · 2025Review
- Effects of ligustrazine on the expression of neurotransmitters in the trigeminal ganglion of a rat migraine model.Annals of translational medicine · 2021Article
- Emodin Interferes With Nitroglycerin-Induced Migraine in Rats Through CGMP-PKG Pathway.Frontiers in pharmacology · 2021Article
- Article
- Expression of artemin and GFRα3 in an animal model of migraine: possible role in the pathogenesis of this disorder.The journal of headache and pain · 2016Article
- sec-Butylpropylacetamide (SPD) has antimigraine properties.Cephalalgia : an international journal of headache · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
Current theory or hypothesis relevant to migraine indicates that trigeminovascular system plays a pivotal role in the pathophysiology of migraine. Particularly, release of neuropeptide and induction of c-fos like immunoreactivity (c-fos LI) within trigeminal nucleus caudalis neurons are regarded as activation markers of trigeminovascular system. In the present study, we set up a rat model for migraine triggered by nitroglycerin (NTG) and coagulated the middle meningeal artery by heating. Using this model, we determined the plasma calcitonin gene-related peptide (CGRP) level as well as the expression of c-fos in trigeminal nucleus caudalis of rats. We found that NTG led to markedly increase in plasma CGRP level and c-fos expression in trigeminal nucleus caudalis compared with the isotonic saline-treated group (P < 0.05). More importantly, heat coagulation of middle meningeal artery could decrease plasma CGRP level and c-fos expression in trigeminal nucleus caudalis (P < 0.05). Heat coagulation of middle meningeal artery may ameliorate sufferings of rat induced by NTG and play an important role in restraining the release of CGRP as well as the activation of neurons in trigeminal nucleus caudalis in rats following NTG infusion.
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