ReviewAnnals of biomedical engineering2011
Activatable T₁ and T₂ magnetic resonance imaging contrast agents.
Review in Annals of biomedical engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 75 citations in OpenAlex.
- Inflammatory microenvironment-responsive MR imaging contrast agents.Nanomedicine (London, England) · 2025Review
- MnCOTheranostics · 2022Article
- Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021Review
- Current approaches and advances in the imaging of stroke.Disease models & mechanisms · 2021Review
- Activatable Nanoparticles: Recent Advances in Redox-Sensitive Magnetic Resonance Contrast Agent Candidates Capable of Detecting Inflammation.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Synthesis and Comparative Evaluation of Photoswitchable Magnetic Resonance Imaging Contrast Agents.ACS omega · 2020Article
- Magnetic Nanoparticles in Cancer Therapy and Diagnosis.Advanced healthcare materials · 2020Review
- Tuning the size and composition of manganese oxide nanoparticles through varying temperature ramp and aging time.PloS one · 2020Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Gold-coated plant virus as computed tomography imaging contrast agent.Beilstein journal of nanotechnology · 2019Article
- A magnetic resonance tuning sensor for the MRI detection of biological targets.Nature protocols · 2018Article
- Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress.Colloids and surfaces. B, Biointerfaces · 2017Article
- Design and Synthesis of New Sulfur-Containing Hyperbranched Polymer and Theranostic Nanomaterials for Bimodal Imaging and Treatment of Cancer.ACS macro letters · 2017Article
- Advances in Monitoring Cell-Based Therapies with Magnetic Resonance Imaging: Future Perspectives.International journal of molecular sciences · 2017Review
- Activatable nanoprobes for biomolecular detection.Current opinion in biotechnology · 2015Review
- MR imaging probes: design and applications.Dalton transactions (Cambridge, England : 2003) · 2015Review
- Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging.Metallomics : integrated biometal science · 2015Review
- Macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases.Theranostics · 2015Review
- Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths.The Analyst · 2014Review
- Redox-triggered self-assembly of gadolinium-based MRI probes for sensing reducing environment.Bioconjugate chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Magnetic resonance imaging (MRI) has become one of the most important diagnosis tools available in medicine. Typically MRI is not capable of sensing biochemical activities. However, recently emerged activatable MRI contrast agents (CAs), whose relaxivity is variable in response to a specific parameter change in the surrounding physiological microenvironment, potentially allow for MRI to indicate biological processes. Among the various factors influencing the relaxivity of a CA, the number of inner-sphere water molecules (q) directly coordinated to the metal center, the residence time of the coordinated water molecule (τ (m)), and the rotational correlation time representing the molecular tumbling time of a complex (τ (R)) contribute strongly to the relaxivity of an activatable CA. Tuning the ligand structure and properties has been the subject of intensive research for activatable MR CA designs. This review summarizes a variety of activatable MRI CAs sensitive to common variables in microenvironment in vivo, i.e., pH, luminescence, metal ions, redox, and enzymes, etc., with emphasis on the influence of ligand design on parameters q, τ (m), and τ (R).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.