ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2011
VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Rate of Revision Surgery and Associated Risk Factors After Primary Arthroscopic ACL Repair With Additional Suture Augmentation.Orthopaedic journal of sports medicine · 2024Article
- Platelet Metabolism and Other Targeted Drugs; Potential Impact on Immunotherapy.Frontiers in oncology · 2018Review
- Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Review
- Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction.Molecular neurobiology · 2015Review
- Why menisci show higher healing rate when repaired during ACL reconstruction? Growth factors release can be the explanation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- Manual khalifa therapy improves functional and morphological outcome of patients with anterior cruciate ligament rupture in the knee: a randomized controlled trial.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Basic science of anterior cruciate ligament injury and repair.Bone & joint research · 2014Article
- New trends in ACL research.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeRecent advances in the treatment of ACL ruptures employ platelet-rich plasma combined with collagen to modulate growth factor release from platelets to stimulate healing. Among the most notable of these growth factors is VEGF, which is a potent mitogen and stimulator of vascular growth and healing. However, the effect of such a growth factor on healing depends on the cellular ability to bind with its receptor. The purpose of this study was to test (1) whether the strength of a tissue-engineered ACL repair is associated with VEGF receptors' mRNA expression of ACL cells and (2) whether age influences this association.
methodNineteen female Yucatan pigs underwent enhanced ACL repair. Biomechanical testing was performed after 15 weeks of healing. Messenger RNA of VEGF receptors 1 and 2 in ACL fibroblasts was assessed by RT-PCR. The ACL structural properties were regressed on receptor expression levels in a multivariate model including serum levels of VEGF, age, and weight as potential confounders.
resultWhile maximum load and linear stiffness were independent of VEGF receptor expression, VEGF receptor 1 was associated with displacement (positively) and yield load (negatively). In a multivariate model of VEGF receptor expression and biomechanics, age was associated with maximum load and yield load.
conclusionThese findings suggest that high VEGF receptor expression, even more so at higher age, results in a more compliant scar, which in turn may lead to greater knee laxity and a compromised clinical result.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.