ReviewReviews in endocrine & metabolic disorders2011
Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain.
Review in Reviews in endocrine & metabolic disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Effect of skipping breakfast on cardiovascular risk factors: a grade-assessed systematic review and meta-analysis of randomized controlled trials and prospective cohort studies.Frontiers in endocrinology · 2023Pooled it
- Influence of sleep restriction on weight loss outcomes associated with caloric restriction.Sleep · 2018Trial
- Navigating the Strengths and Constraints of Mouse Models in Obesity Research.Endocrinology · 2025Review
- Ghrelin regulating liver activity and its potential effects on liver fibrosis andFrontiers in cellular and infection microbiology · 2023Review
- Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression.Biomolecules · 2022Review
- The Effects of Leptin on Glial Cells in Neurological Diseases.Frontiers in neuroscience · 2019Review
- Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin.Frontiers in endocrinology · 2018Review
- The role of leptin in central nervous system diseases.Neuroreport · 2016Review
- The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis.Molecular metabolism · 2015Article
- Anorexia: an early sign of fourth ventricle astrocytoma in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Attenuation of saccharin-seeking in rats by orexin/hypocretin receptor 1 antagonist.Psychopharmacology · 2013Article
- Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.Cell death & disease · 2013Article
- Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the past two decades, two major discoveries have greatly contributed to our current knowledge on the central control of food intake and body-weight; the discovery of the anorexigenic adipocyte derived hormone leptin in 1994 and the orexigenic gut derived hormone ghrelin in 1999. Both hormones act as crucial signals to indicate nutritional status as well as to modulate feeding behaviour through a variety of distinct pathways. They target overlapping CNS regions in order to mediate their obvious opposing effects on energy balance. Here we depict the integral picture of leptin and ghrelin on central regulation of food intake by reviewing their actions across the CNS, in regions of the hypothalamus, brainstem, mesolimbic reward pathway and other higher brain areas.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.