Trial reportEuropean journal of applied physiology2011
Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hormone plasma levels in female swimmers.
Trial report in European journal of applied physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Effects of lemon verbena extract (Recoverben®) supplementation on muscle strength and recovery after exhaustive exercise: a randomized, placebo-controlled trial.Journal of the International Society of Sports Nutrition · 2018Trial
- Effect of polyphenol supplements on redox status of blood cells: a randomized controlled exercise training trial.European journal of nutrition · 2015Trial
- Diet supplementation with DHA-enriched food in football players during training season enhances the mitochondrial antioxidant capabilities in blood mononuclear cells.European journal of nutrition · 2015Trial
- Role of arbutin and acetoside against Parkinson's disease.Indian journal of pharmacology · 2026Review
- Acteoside as a multifunctional natural glycoside: therapeutic potential across various diseases.Inflammopharmacology · 2025Review
- Acteoside as a multifunctional natural glycoside: therapeutic potential across various diseases.Inflammopharmacology · 2025Review
- Cytotoxic Effects of Verbascoside on MCF-7 and MDA-MB-231Turkish journal of pharmaceutical sciences · 2021Article
- Impact of Nutrition-Based Interventions on Athletic Performance during Menstrual Cycle Phases: A Review.International journal of environmental research and public health · 2021Review
- Antioxidant Supplementation Modulates Neutrophil Inflammatory Response to Exercise-Induced Stress.Antioxidants (Basel, Switzerland) · 2020Article
- Metabolic Syndrome is Associated with Oxidative Stress and Proinflammatory State.Antioxidants (Basel, Switzerland) · 2020Article
- Relationships Between Chemical Structure and Antioxidant Activity of Isolated Phytocompounds from Lemon Verbena.Antioxidants (Basel, Switzerland) · 2019Article
- Article
- Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People.Nutrients · 2018Article
- Oxidative Stress in Female Athletes Using Combined Oral Contraceptives.Sports medicine - open · 2016Article
- Article
- Anti-Fatigue and Antioxidant Activity of the Polysaccharides Isolated from Millettiae speciosae Champ. Leguminosae.Nutrients · 2015Article
- Hepatoprotective effect of 17β-estradiol as antioxidant modulators against stress damage.Hepatitis monthly · 2015Article
- Prooxidant effects of verbascoside, a bioactive compound from olive oil mill wastewater, on in vitro developmental potential of ovine prepubertal oocytes and bioenergetic/oxidative stress parameters of fresh and vitrified oocytes.BioMed research international · 2014Article
- Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee.Biology of sex differences · 2013Article
- Effects of pulse current on endurance exercise and its anti-fatigue properties in the hepatic tissue of trained rats.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to investigate the effects of diet supplementation with phytoestrogens on sex hormone levels, antioxidant adaptive responses and oxidative damage induced by exercise. Ten female swimmers participated for 26 days in a diet intervention with either a functional beverage rich in vitamins C and E or the same beverage but also supplemented with Lippia citriodora extract (PLX) containing 20 mg/100 ml verbascoside. After the intervention all subjects participated in a swimming session for 30 min maintaining the intensity at about 75-80% of their individual best performance time for a 50-m swim. In lymphocytes, the superoxide dismutase activity increased after exercise, with a higher increase in the PLX group. Swimming increased the erythrocyte activity of glutathione peroxidase and glutathione reductase in the PLX group. Purified glutathione reductase activity increased after an in vitro incubation with PLX. No effects were observed on the lymphocyte levels of malondialdehyde and carbonyls, but exercise increased the percentage of high-damaged lymphocytes 2.8 times in the placebo group and 1.5 times in the PLX group. PLX decreased the levels of 17-β-estradiol and testosterone and increased the levels of the sex hormone binding globulin. In conclusion, supplementation with phytoestrogens enhances the glutathione-dependent enzyme activities in erythrocytes and the superoxide dismutase activity in lymphocytes in response to exercise. PLX also shows direct antioxidant properties, by increasing glutathione reductase enzyme activity in vitro. Supplementation with phytoestrogens also decreases the plasma steroid hormone levels, pointing towards a possible agonistic effect of verbascoside in the hypothalamic regulation of estradiol synthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.