ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012
Prevalence of clinically relevant oral mucositis in outpatients receiving myelosuppressive chemotherapy for solid tumors.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04308161 (The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Nuclear Receptors and Stress Response Pathways Associated with the Development of Oral Mucositis Induced by Antineoplastic Agents.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Evaluation of oral mucositis level and affecting factors in cancer patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Article
- Effectiveness of intraoral stents in reducing oral adverse events during radiotherapy for maxillary or nasal cavity malignant tumors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Impact of systemic dexamethasone dosage on docetaxel-induced oral mucositis in patients with breast cancer.Scientific reports · 2023Article
- J-SUPPORT research policy for oral mucositis associated with cancer treatment.Cancer medicine · 2022Article
- Confounding factors in the assessment of oral mucositis in head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Review
- Impact of systemic dexamethasone administration on oral mucositis induced by anthracycline-containing regimens in breast cancer treatment.Scientific reports · 2022Article
- Risk factors for oral mucositis during chemotherapy treatment for solid tumors: a retrospective STROBE-guided study.Medicina oral, patologia oral y cirugia bucal · 2022Article
- The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma.Frontiers in oral health · 2022Article
- Assessment and prevalence of concomitant chemo-radiotherapy-induced oral mucositis in patients with oral squamous cell carcinomaTurkish journal of medical sciences · 2021Article
- Leveraging Patient Reported Outcomes Measurement via the Electronic Health Record to Connect Patients with Cancer to Smoking Cessation Treatment.International journal of environmental research and public health · 2020Article
- Current Trends in Management of Oral Mucositis in Cancer TreatmentAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Bacterial Pneumonia in Patients with Cancer: Novel Risk Factors and Management.Clinics in chest medicine · 2017Review
- Chronic oral mucositis after radiotherapy to the head and neck: a new insight.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Oral health status of chinese paediatric and adolescent oncology patients with chemotherapy in Hong Kong: a pilot study.The open dentistry journal · 2015Article
- The impact of smoking on the clinical outcome of locoregionally advanced nasopharyngeal carcinoma after chemoradiotherapy.Radiation oncology (London, England) · 2014Article
- Tobacco use in the oncology setting: advancing clinical practice and research.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Glycemic Excursion, Adverse Drug Reactions, and Self-Management in Diabetes Patients Undergoing Chemotherapy: A Literature Review.Asia-Pacific journal of oncology nursingReview
- Radiation-induced Oral Mucositis in Brazilian Patients: Prevalence and Associated Factors.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChemotherapy-induced oral mucositis (CIOM) is a common side effect of cancer therapy that may lead to significant morbidity and interfere with the treatment plan. The present prospective, cross-sectional study intended to describe the prevalence of clinically relevant CIOM (CRCIOM) in outpatients receiving chemotherapy for solid tumors.
methodsIntra-oral assessments were performed on 298 consecutively recruited patients, who had undergone at least 14 days of chemotherapy for solid tumors in our outpatient oncology department. The presence of CIOM was evaluated using the Oral Mucositis Assessment Scale. CRCIOM was defined as the presence of ulcers (≥ 1 cm(2)), severe erythema, and/or inability to eat solid foods (WHO grades 2-4). Furthermore, the current levels of oral hygiene and oral health were measured.
resultsA low prevalence (18 patients, 6%) of CRCIOM was found in the investigated patient collective, including 1% of patients with severe (WHO grade 3/4) CIOM. In the CRCIOM group, 16 patients were male, and two were female; 8 patients with CRCIOM had received head and neck radiotherapy. A higher prevalence of CRCIOM was found in smoking patients (12.7% vs. 4.5%, p < 0.05) and in the patients who have not had a dental checkup within the preceding 12 months (11.2% vs. 3.0%, p < 0.01). Diabetes mellitus and low WBC appeared not to be associated with higher CRCIOM rates. The plaque and gingival indexes were significantly increased (p < 0.01) in the CRCIOM group.
conclusionsAlthough CRCIOM was a rare event in the investigated patient population, our results emphasize that pre-treatment dental therapy and primary preventive measures (including oral hygiene instructions) can be improved. Before starting chemotherapy, increased awareness of individual risk factors, such as male sex, tobacco smoking, low dental checkup frequency, poor oral hygiene, and a reduced oral health status, could help to prevent CRCIOM.
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