ArticleGastroenterology research and practice2010
TLRs, Alcohol, HCV, and Tumorigenesis.
Article in Gastroenterology research and practice, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Molecular Changes in Relation to Alcohol Consumption and Hepatocellular Carcinoma.International journal of molecular sciences · 2022Review
- Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway.Open medicine (Warsaw, Poland) · 2022Article
- MRC-5 Cancer-associated Fibroblasts Influence Production of Cancer Stem Cell Markers and Inflammation-associated Cell Surface Molecules, in Liver Cancer Cell Lines.International journal of medical sciences · 2019Article
- Role of cytokines and chemokines in alcohol-induced tumor promotion.OncoTargets and therapy · 2017Review
- Toll-like receptors in pathophysiology of liver diseases.World journal of hepatology · 2016Review
- Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients.Molecular cancer therapeutics · 2015Article
- Hepatitis C, innate immunity and alcohol: friends or foes?Biomolecules · 2015Review
- Alcohol and hepatocellular carcinoma: a review and a point of view.World journal of gastroenterology · 2014Review
- SALL4 immunoreactivity predicts prognosis in Western hepatocellular carcinoma patients but is a rare event: a study of 236 cases.The American journal of surgical pathology · 2014Article
- Chemoprevention of hepatocellular carcinoma in patients with hepatitis C virus related cirrhosis.World journal of hepatology · 2013Review
- Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?Cancer management and research · 2012Article
- Stem cells in liver diseases and cancer: recent advances on the path to new therapies.Hepatology (Baltimore, Md.) · 2012Review
- The role of innate immunity in the pathogenesis of preneoplasia in drug-induced chronic hepatitis based on a mouse model.Experimental and molecular pathology · 2011Review
- Toll-like receptors signaling contributes to immunopathogenesis of HBV infection.Gastroenterology research and practice · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases. Alcoholism is associated with endotoxemia that stimulates expression of proinflammatory cytokine expression and inflammation in the liver and fat tissues. Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines. Synergism between alcohol and HCV may lead to liver tumorigenesis through TLR signaling.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.