ReviewJournal of biomedicine & biotechnology2011
Animal models for periodontal disease.
Review in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
133 citing papers in PubMed, 3 syntheses or guidelines pooled it, 306 citations in OpenAlex.
- Stem cell therapies for periodontal tissue regeneration: a network meta-analysis of preclinical studies.Stem cell research & therapy · 2020Pooled it
- Photodynamic antimicrobial chemotherapy has an overt killing effect on periodontal pathogens? A systematic review of experimental studies.Lasers in medical science · 2019Pooled it
- Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies.Nutrients · 2019Pooled it
- Alleviating effects of KGC19b on periodontal inflammation through anti-inflammatory and induction of osteogenic differentiation inJournal of ginseng research · 2026Article
- Resveratrol supplementation as a non-surgical treatment in periodontitis and related systemic conditions.Journal of traditional and complementary medicine · 2026Review
- N-Acetylcysteine Reduces Alveolar Bone Loss and Mitigates Systemic Oxidative Damage in Rats With Apical Periodontitis.International endodontic journal · 2026Article
- Maxillary second molar root fusion: incidence and relationship with alveolar bone loss in ICR mice.Journal of periodontal & implant science · 2026Article
- Multifunctional implantable hydrogels: Smart platforms at the forefront of biomedical innovation.Materials today. Bio · 2026Review
- Pharmacological investigation of bergapten isolated from Glehnia littoralis against periodontitis.Scientific reports · 2026Article
- Adjunctive Therapies in Periodontitis: Current Concepts and the Future.Journal of periodontal research · 2026Review
- MicroRNA-driven periodontal immune homeostasis and tissue regeneration: from regulatory networks to engineering translation.Frontiers in immunology · 2026Review
- Murine Models of Experimental Periodontal Disease.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A Mouse Model for Fusobacterium nucleatum-Mediated Experimental Periodontitis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Modeling chronic periodontitis in rats: Persistent alveolar bone loss mediated by periodontal pathogens.Animal models and experimental medicine · 2025Article
- The Impact of Scaling and Root Planing onArchives of Razi Institute · 2025Article
- Guidance on the assessment of the functionality of biomaterials for periodontal tissue regeneration: Methodologies and testing procedures.Dental materials : official publication of the Academy of Dental Materials · 2025Review
- Application of Single-Cell Genomics to Animal Models of Periodontitis and Peri-Implantitis.Journal of clinical periodontology · 2025Review
- Underscoring long-term host-microbiome interactions in a physiologically relevant gingival tissue model.NPJ biofilms and microbiomes · 2025Article
- Insights into periodontal disease: comparative analysis of animal models.Frontiers in dental medicine · 2025Review
- Tooth wear and dental calculus in a group of orca (Journal of the Royal Society of New Zealand · 2025Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro. Among the animal kingdom, rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages. Periodontitis commonly has been induced by placing a bacterial plaque retentive ligature in the gingival sulcus around the molar teeth. In addition, alveolar bone loss has been induced by inoculation or injection of human oral bacteria (e.g., Porphyromonas gingivalis) in different animal models. While animal models have provided a wide range of important data, it is sometimes difficult to determine whether the findings are applicable to humans. In addition, variability in host responses to bacterial infection among individuals contributes significantly to the expression of periodontal diseases. A practical and highly reproducible model that truly mimics the natural pathogenesis of human periodontal disease has yet to be developed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.