Evidence map›Paper›PMID 21331321›Full record

ArticleHIV therapy2010

Recent developments in HIV-related kidney disease.

Michelle M Estrella, Derek M Fine, Mohamed G Atta

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in HIV therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01869010 completednot on this map

Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2010 to 2012Enrolled30ConditionsHIV InfectionArmsLow sodium water overload in HIV tenofovir, HIV no tenofovir and seronegative controls
NCT04087239 active not recruitingnot on this mapstarted 2016, after this paper: background citation

HIV Exposure, Disease Acquisition and Progression Among Children: Role of Maternal Immunogenetics, Viral Genetic Diversity, HAART Exposure, Co-morbidities and Psycho-Social Status: (UZ-CHS Birth Cohort)

TypeobservationalSponsorUniversity of ZimbabweRan2016 to 2035Enrolled1,200ConditionsHIV Infections, Immune Activation, ComorbiditiesArmsHIV
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Impaired Urine Dilution Capability in HIV Stable Patients.International journal of nephrology · 2014
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Michelle M EstrellaJohns Hopkins University School of Medicine, Division of Nephrology, 1830 E Monument Street, Suite 416, Baltimore, MD 21205, USA.
Derek M Fine
Mohamed G Atta
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Burden of Chronic Kidney Disease in HIV InfectionK23DK081317 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ESTRELLA, MICHELLE M · 2009 to 2013
$835k
NIDDK NIH HHS K23 DK081317
6 · The paper itself

Abstract

Although kidney disease has been a recognized complication of HIV infection since the beginning of the HIV epidemic, its epidemiology, underlying causes and treatment have evolved in developed countries where HAART has been widely available. HIV-associated nephropathy and HIV immune complex-mediated kidney disease were the prominent renal diagnoses in the earlier period of the HIV epidemic. While HIV immune complex-mediated kidney disease remains a common finding among HIV-infected individuals with kidney disease, the incidence of HIV-associated nephropathy has been diminishing in developed countries. The role of the metabolic effects of long-term HAART exposure and nephrotoxicity of certain antiretroviral medications on the development and progression of chronic kidney disease is now of increasing concern. The long-term clinical implications of acute kidney injury among HIV-infected persons are increasingly recognized. Kidney disease in HIV-infected persons continues to be a major risk factor for morbidity and mortality in this patient population; therefore, early recognition and treatment of kidney disease are imperative in lessening the impact of kidney disease on the health of HIV-infected individuals. This review focuses on recent developments and ongoing challenges in the understanding, diagnosis and management of HIV-related kidney disease.

Identifiers

PMID21331321
PMCPMC3038636
OpenAlexW2042888843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.