ArticleComputational and mathematical methods in medicine2011
How hyperpolarization and the recovery of excitability affect propagation through a virtual anode in the heart.
Article in Computational and mathematical methods in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia.Frontiers in physiology · 2019Article
- Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?Frontiers in physiology · 2019Review
- A Simplified Approach for Simultaneous Measurements of Wavefront Velocity and Curvature in the Heart Using Activation Times.Cardiovascular engineering and technology · 2013Article
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Authors and funding
2 authors.
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Abstract
Researchers have suggested that the fate of a shock-induced wave front at the edge of a "virtual anode" (a region hyperpolarized by the shock) is a key factor determining success or failure during defibrillation of the heart. In this paper, we use a simple one-dimensional computer model to examine propagation speed through a hyperpolarized region. Our goal is to test the hypothesis that rapid propagation through a virtual anode can cause failure of propagation at the edge of the virtual anode. The calculations support this hypothesis and suggest that the time constant of the sodium inactivation gate is an important parameter. These results may be significant in understanding the mechanism of the upper limit of vulnerability.
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