ArticleCommunicative & integrative biology2010
Roles of Ca and secretory pathway Ca-ATPase pump type 1 (SPCA1) in intra-Golgi transport.
Article in Communicative & integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- The impact of manganese on vascular endothelium.Toxicological research · 2024Review
- Structure and transport mechanism of the human calcium pump SPCA1.Cell research · 2023Article
- Mosaic variant in ATP2C1 presenting as relapsing linear acantholytic dermatosis.The British journal of dermatology · 2020Article
- Calcium Signaling in ß-cell Physiology and Pathology: A Revisit.International journal of molecular sciences · 2019Review
- Friend and foe: β-cell CaMolecular metabolism · 2019Review
- The Trans Golgi Region is a Labile Intracellular CaScientific reports · 2018Article
- The key target of neuroprotection after the onset of ischemic stroke: secretory pathway Ca(2+)-ATPase 1.Neural regeneration research · 2015Article
- Control systems and coordination protocols of the secretory pathway.F1000prime reports · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanisms for intra-Golgi transport remain a hotly debated topic. Recently, we published data illuminating a new aspect involved in intra-Golgi transport, namely a release of free cytosolic Ca(2+) ([Ca(2+)](cyt)) from the lumen of Golgi cisternae that is fundamental for the secretion and the progression of newly synthesized proteins through the Golgi apparatus (GA). This increase in [Ca(2+)](cyt) during the late stage of synchronous intra-Golgi transport stimulates the fusion of membranes containing cargo proteins and Golgi cisternae, allowing the progression of proteins through the GA. Subsequent restoration of the basal [Ca(2+)](cyt) is also important for the delivery of cargo to the proper final destination. Additionally, the secretory pathway Ca(2+)-ATPase Ca(2+) pump (SPCA1) plays an essential role at this stage. The fine regulation of membrane fusion is also important for the formation and the maintenance of the Golgi ribbon and SPCA1, which regulates [Ca(2+)](cyt) levels, can be considered a controller of trafficking. This evidence contradicts a model of intra-Golgi transport in which permanent membrane continuity allows cargo diffusion and progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.