ArticleJournal of young pharmacists : JYP2010
Anti-allergic Activity of Stem Bark of Myrica esculenta Buch.-Ham. (Myricaceae).
Article in Journal of young pharmacists : JYP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 42 citations in OpenAlex.
- Therapeutic opportunities of edible antiviral plants for COVID-19.Molecular and cellular biochemistry · 2021Review
- Review
- Diarylheptanoids as nutraceutical: A review.Biocatalysis and agricultural biotechnology · 2019Review
- Some medicinal plants with antiasthmatic potential: a current status.Asian Pacific journal of tropical biomedicine · 2011Review
- Pharmacognostic characterization of Myrica esculenta leaves.Journal of Ayurveda and integrative medicineArticle
- Neuroprotective potential of Myrica esulenta in Haloperidol induced Parkinson's disease.Journal of Ayurveda and integrative medicineArticle
- Evaluation for substitution of stem bark with small branches of Myrica esculenta for medicinal use - A comparative phytochemical study.Journal of Ayurveda and integrative medicineArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic diseases, such as allergic asthma, are hypersensitivity reactions initiated by immunological mechanisms. Myrica esculenta (M. esculenta) is known traditionally in Ayurveda to possess anti-asthmatic activity. The present investigation was undertaken to evaluate the effect of crude extract of stem bark of M. esculenta (Family Myricaceae, commonly known as Kaiphal) on experimental allergic reactions. Experimental models studied were allergic pleurisy and vascular permeability induced by acetic acid in mice. Pretreatment with M. esculenta (75 mg/kg and 150 mg/kg, p.o.) significantly inhibited the eosinophil accumulation (P < 0.01) respectively in the pleural cavity. M. esculenta (75 and 150 mg/kg, p.o.) significantly inhibited the rise in plasma exudation (57.12% and 59.77%, P < 0.01) induced by acetic acid in mice. These findings demonstrate that the crude extract from the stem bark of M. esculenta possesses antiallergic activity. This activity may be mediated by reducing the release of mediators such as histamine, inhibition of mast cell degranulation, and inhibition of eosinophil accumulation thereby preventing the release of cytokines and chemokines.
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