ArticleEMBO reports2011
Symmetrical modification within a nucleosome is not required globally for histone lysine methylation.
Article in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- The Inherent Asymmetry of DNA Replication.Annual review of cell and developmental biology · 2017Review
- Symmetry from Asymmetry or Asymmetry from Symmetry?Cold Spring Harbor symposia on quantitative biology · 2017Article
- Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and Their Modifications.ACS chemical biology · 2016Article
- Review
- Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability.Genes & development · 2015Article
- 'Memory and molecular turnover,' 30 years after inception.Epigenetics & chromatin · 2014Review
- Identification and interrogation of combinatorial histone modifications.Frontiers in genetics · 2013Review
- Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.The Journal of biological chemistry · 2013Article
- H3.3-H4 tetramer splitting events feature cell-type specific enhancers.PLoS genetics · 2013Article
- Proteomics in epigenetics: new perspectives for cancer research.Briefings in functional genomics · 2013Review
- Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Asymmetrically modified nucleosomes.Cell · 2012Article
- A model for mitotic inheritance of histone lysine methylation.EMBO reports · 2011Article
- Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.EMBO reports · 2011Article
- Breaking the histone code with quantitative mass spectrometry.Expert review of proteomics · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two copies of each core histone exist in every nucleosome; however, it is not known whether both histones within a nucleosome are required to be symmetrically methylated at the same lysine residues. We report that for most lysine methylation states, wild-type histones paired with mutant, unmethylatable histones in mononucleosomes have comparable methylation levels to bulk histones. Our results indicate that symmetrical histone methylation is not required on a global scale. However, wild-type H4 histones paired with unmethylatable H4K20R histones showed reduced levels of H4K20me2 and H4K20me3, suggesting that some fractions of these modifications might exist symmetrically, and enzymes mediating these modifications might, to some extent, favour nucleosome substrates with premethylated H4K20.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.