ArticleEMBO reports2011
Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E.
Article in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Regulatory role of the Cpx ESR in bacterial behaviours.Virulence · 2024Review
- Article
- Neuromodulators as Interdomain Signaling Molecules Capable of Occupying Effector Binding Sites in Bacterial Transcription Factors.International journal of molecular sciences · 2023Article
- Review
- Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk.Frontiers in microbiology · 2021Review
- Inter-Kingdom Signaling of Stress Hormones: Sensing, Transport and Modulation of Bacterial Physiology.Frontiers in microbiology · 2021Review
- Identification of Genes Involved in Biogenesis of Outer Membrane Vesicles (OMVs) inFrontiers in microbiology · 2019Article
- Contribution of the Cpx envelope stress system to metabolism and virulence regulation in Salmonella enterica serovar Typhimurium.PloS one · 2019Article
- Peptides as Quorum Sensing Molecules: Measurement Techniques and Obtained LevelsFrontiers in neuroscience · 2017Review
- Intra-Species and Inter-Kingdom Signaling ofFrontiers in microbiology · 2017Review
- Gut Dysbiosis in Animals Due to Environmental Chemical Exposures.Frontiers in cellular and infection microbiology · 2017Review
- Review
- Experimental approaches to identify small RNAs and their diverse roles in bacteria--what we have learnt in one decade of MicA research.MicrobiologyOpen · 2015Review
- Article
- Prokaryotes Versus Eukaryotes: Who is Hosting Whom?Frontiers in veterinary science · 2014Review
- The Dynamic Interactions between Salmonella and the Microbiota, within the Challenging Niche of the Gastrointestinal Tract.International scholarly research notices · 2014Review
- Antivirulence therapy for animal production: filling an arsenal with novel weapons for sustainable disease control.PLoS pathogens · 2013Review
- Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica.BMC microbiology · 2012Article
- A central metabolic circuit controlled by QseC in pathogenic Escherichia coli.Molecular microbiology · 2011Article
- Stress in the microbiome-immune crosstalk.Gut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Salmonella enterica serovar Typhi (S. typhi) causes typhoid fever. We show that exposure of S. typhi to neuroendocrine stress hormones results in haemolysis, which is associated with the release of haemolysin E in membrane vesicles. This effect is attributed to increased expression of the small RNA micA and RNA chaperone Hfq, with concomitant downregulation of outer membrane protein A. Deletion of micA or the two-component signal-transduction system, CpxAR, abolishes the phenotype. The hormone response is inhibited by the β-blocker propranolol. We provide mechanistic insights into the basis of neuroendocrine hormone-mediated haemolysis by S. typhi, increasing our understanding of inter-kingdom signalling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.