ArticleJournal of perinatology : official journal of the California Perinatal Association2011
Effect of pasteurization on selected immune components of donated human breast milk.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 126 citations in OpenAlex.
- DoMINO: Donor milk for improved neurodevelopmental outcomes.BMC pediatrics · 2014Trial
- TGF-β2, a protective intestinal cytokine, is abundant in maternal human milk and human-derived fortifiers but not in donor human milk.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2013Trial
- Short outcomes of donor milk and mother's own milk for preterm infants.Pediatric research · 2026Article
- An investigation into the status of human milk feeding in very low birth weight infants: a multicenter study.International breastfeeding journal · 2026Observational
- Effects of Holder Pasteurization on 15-F2t-Isoprostane and Total Antioxidant Power in Donor Human Milk.Biomolecules · 2026Article
- Ultraviolet-C Treatment Better Preserves the Proteomic Profile of Donor Human Milk than Holder Pasteurization.Journal of agricultural and food chemistry · 2025Article
- Donor human milk pasteurization methods and the effect on milk components as they relate to Necrotizing enterocolitis.Seminars in fetal & neonatal medicine · 2025Review
- Examining associations between human milk fatty acids, oligosaccharides, and early infant cognitive, language and motor development in the CHILD cohort study.Frontiers in nutrition · 2025Article
- Perspectives of healthcare workers on the acceptability of donor human milk banking in Southwest Nigeria.International breastfeeding journal · 2024Article
- Effect of Holder Pasteurization, Mode of Delivery, and Infant's Gender on Fatty Acid Composition of Donor Breast Milk.Nutrients · 2024Article
- Donor human milk: the influence of processing technologies on its nutritional and microbial composition.Frontiers in nutrition · 2024Review
- The association of different types of human milk with bronchopulmonary dysplasia in preterm infants.Frontiers in nutrition · 2024Article
- Key biologically active components of breast milk and their beneficial effects.Seminars in pediatric surgery · 2023Review
- Preservation of Anti-cytomegalovirus Activity in Human Milk Following High-Pressure Processing Compared to Holder Pasteurization.Frontiers in nutrition · 2022Article
- Clinical implications of preterm infant gut microbiome development.Nature microbiology · 2022Article
- Structural and functional changes of bioactive proteins in donor human milk treated by vat-pasteurization, retort sterilization, ultra-high-temperature sterilization, freeze-thawing and homogenization.Frontiers in nutrition · 2022Article
- Impact of Oropharyngeal Administration of Colostrum in Preterm Newborns' Oral Microbiome.Nutrients · 2021Observational
- Review
- Immunomodulatory Effects of Human Colostrum and Milk.Pediatric gastroenterology, hepatology & nutrition · 2021Review
- Comparison of the Effect of Holder Pasteurization and High-Pressure Processing on Human Milk Bacterial Load and Bioactive Factors Preservation.Journal of pediatric gastroenterology and nutrition · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePasteurized, donated milk is increasingly provided to preterm infants in the absence of mother's own milk. The aim of this study was to determine the effect of pasteurization on the concentration of selected components in donated human breast milk. STUDY
designDonated milk from 34 mothers was pooled into 17 distinct batches (4 mothers per batch). Aliquots of each batch were then Holder pasteurized (62.5 °C for 30 min). Interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70 and IL-13 were measured in a multiplex enzyme-linked immunosorbent assay (ELISA). Granulocyte colony-stimulating factor (G-CSF), heparin-binding epidermal-like growth factor (HB-EGF) and hepatocyte growth factor (HGF) were measured by ELISA. Lipids were assessed by gas chromatography and gangliosides by the resorcinol-HCl reaction.
resultIFN-γ, TNF-α, IL-1β, IL-10 and HGF were significantly reduced by pasteurization (P<0.05). Gangliosides were not affected, but the proportion of medium-chain saturated fats was increased (P<0.05) with a trend towards a decreased proportion of oleic acid (P=0.057).
conclusionPasteurization significantly reduced the concentration of several immunoactive compounds present in breast milk, but did not have an impact on others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.