ArticleBlood2011
cpsf1 is required for definitive HSC survival in zebrafish.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Exploring hematopoiesis in zebrafish using forward genetic screening.Experimental & molecular medicine · 2024Review
- Poly (A)-specific ribonuclease deficiency impacts oogenesis in zebrafish.Scientific reports · 2023Article
- Zebrafish models of acute leukemias: Current models and future directions.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells.Oncogene · 2021Article
- CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection.Human molecular genetics · 2019Article
- Targeting cleavage and polyadenylation specific factor 1 via shRNA inhibits cell proliferation in human ovarian cancer.Journal of biosciences · 2017Article
- Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish.FEBS letters · 2016Review
- Engineering Hematopoietic Stem Cells: Lessons from Development.Cell stem cell · 2016Review
- TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis.PLoS genetics · 2015Article
- A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.Molecular and cellular biology · 2015Article
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- Transcriptome analysis of the white body of the squid Euprymna tasmanica with emphasis on immune and hematopoietic gene discovery.PloS one · 2015Article
- Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish.Cell discovery · 2015Article
- A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.Developmental cell · 2014Article
- Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.Developmental biology · 2013Article
- Myelopoiesis and myeloid leukaemogenesis in the zebrafish.Advances in hematology · 2012Article
- A model 450 million years in the making: zebrafish and vertebrate immunity.Disease models & mechanisms · 2012Review
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Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
A comprehensive understanding of the genes and pathways regulating hematopoiesis is needed to identify genes causally related to bone marrow failure syndromes, myelodysplastic syndromes, and hematopoietic neoplasms. To identify novel genes involved in hematopoiesis, we performed an ethyl-nitrosourea mutagenesis screen in zebrafish (Danio rerio) to search for mutants with defective definitive hematopoiesis. We report the recovery and analysis of the grechetto mutant, which harbors an inactivating mutation in cleavage and polyadenylation specificity factor 1 (cpsf1), a gene ubiquitously expressed and required for 3' untranslated region processing of a subset of pre-mRNAs. grechetto mutants undergo normal primitive hematopoiesis and specify appropriate numbers of definitive HSCs at 36 hours postfertilization. However, when HSCs migrate to the caudal hematopoietic tissue at 3 days postfertilization, their numbers start decreasing as a result of apoptotic cell death. Consistent with Cpsf1 function, c-myb:EGFP(+) cells in grechetto mutants also show defective polyadenylation of snrnp70, a gene required for HSC development. By 5 days postfertilization, definitive hematopoiesis is compromised and severely decreased blood cell numbers are observed across the myeloid, erythroid, and lymphoid cell lineages. These studies show that cpsf1 is essential for HSC survival and differentiation in caudal hematopoietic tissue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.