ArticleAJNR. American journal of neuroradiology2011
Potential of integrated [18F] fluorodeoxyglucose positron-emission tomography/CT in identifying vulnerable carotid plaques.
Article in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Molecular imaging of carotid artery atherosclerosis with PET: a systematic review.European journal of nuclear medicine and molecular imaging · 2020Pooled it
- Pooled it
- European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2018Pooled it
- Prognostic value of plaque burden on computed tomography angiography in patients with symptomatic carotid artery disease.European stroke journal · 2026Article
- Stroke and molecular imaging: a focus on FDG-PET.American journal of nuclear medicine and molecular imaging · 2023Review
- Emerging Role of Carotid MRI for Personalized Ischemic Stroke Risk Prediction in Patients With Carotid Artery Stenosis.Frontiers in neurology · 2021Review
- PET/MRI of atherosclerosis.Cardiovascular diagnosis and therapy · 2020Review
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Predictive medicine: towards a multi-parametric imaging for a personal risk stratification.European journal of nuclear medicine and molecular imaging · 2017Article
- Variability in quantitative analysis of atherosclerotic plaque inflammation using 18F-FDG PET/CT.PloS one · 2017Article
- Article
- High-risk plaque features can be detected in non-stenotic carotid plaques of patients with ischaemic stroke classified as cryptogenic using combined (18)F-FDG PET/MR imaging.European journal of nuclear medicine and molecular imaging · 2016Article
- Neuroimaging of the vulnerable plaque.Current vascular pharmacology · 2015Review
- Molecular imaging in atherosclerosis: FDG PET.Current atherosclerosis reports · 2012Review
- Sonographic characteristics of carotid artery plaques: Implications for follow-up planning?Journal of ultrasound · 2012Article
- Role ofWorld journal of nuclear medicineReview
- Inter-reader agreement ofJRSM cardiovascular diseaseArticle
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is a need for improved risk stratification of patients with TIA/stroke and carotid atherosclerosis. The purpose of this study was to prospectively investigate the potential of integrated (18)F-FDG PET/MDCT in identifying vulnerable carotid plaques. MATERIALS AND
methodsFifty patients with TIA/stroke with an ipsilateral carotid plaque causing <70% stenosis and a plaque on the contralateral asymptomatic side underwent integrated (18)F-FDG PET/MDCT within 36.1 ± 20.0 days (range, 9-95 days) of the last symptoms. Carotid plaque (18)F-FDG uptake was measured as both the mean and maximum blood-normalized SUV, known as the TBR. Using MDCT, we assessed volumes of vessel wall and individual plaque components.
resultsMean TBR was only significantly larger in the ipsilateral plaques of patients who were imaged within 38 days (1.24 ± 0.04 [SE] versus 1.17 ± 0.05, P = .014). This also accounted for maximum TBR (1.53 ± 0.06 versus 1.42 ± 0.06, P = .015). MDCT-assessed vessel wall and LRNC volumes were larger in ipsilateral plaques of all patients (982.3 ± 121.3 versus 811.3 ± 106.6 mm(3), P = .016; 164.7 ± 26.1 versus 134.3 ± 35.2 mm(3), P = .026, respectively).
conclusionsIn the present study, (18)F-FDG PET only detected significant differences between ipsilateral and contralateral asymptomatic plaques in patients with TIA/stroke who were imaged within 38 days, whereas MDCT detected larger vessel wall and LRNC volumes, regardless of time after symptoms. In view of the substantial overlap in measurements of both sides, it remains to be determined whether the differences we found will be clinically meaningful.
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