ArticleBriefings in bioinformatics2011
The what, where, how and why of gene ontology--a primer for bioinformaticians.
Article in Briefings in bioinformatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
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- Transcriptomic profiling of milk fat globules in cows with different β-casein genotypes.Scientific reports · 2025Article
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- Gene regulation and signaling pathways in immune response to respiratory sensitizers: a database analysis.Frontiers in immunology · 2025Article
- Generation of 12Computational and structural biotechnology journal · 2025Article
- DEL-Thyroid: deep ensemble learning framework for detection of thyroid cancer progression through genomic mutation.BMC medical informatics and decision making · 2024Article
- Dissecting the complex genetic basis of pre- and post-harvest traits inHorticulture research · 2024Article
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- Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics.Cells · 2023Article
- Genome-wide identification, classification, and characterization of lectin gene superfamily in sweet orange (Citrus sinensis L.).PloS one · 2023Article
- Integration of probabilistic functional networks without an external Gold Standard.BMC bioinformatics · 2022Article
- Identifying significant genes and functionally enriched pathways in familial hypercholesterolemia using integrated gene co-expression network analysis.Saudi journal of biological sciences · 2022Article
- Transcriptional effects of electroporation on Echinococcus multilocularis primary cell culture.Parasitology research · 2022Article
- RETRACTED: Molecular mechanism of inhibitory effects of melatonin on prostate cancer cell proliferation, migration and invasion.PloS one · 2022Article
- Identification of Biomarker in Brain-specific Gene Regulatory Network Using Structural Controllability Analysis.Frontiers in bioinformatics · 2022Article
- Biochemical Mapping ofInternational journal of molecular sciences · 2021Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
With high-throughput technologies providing vast amounts of data, it has become more important to provide systematic, quality annotations. The Gene Ontology (GO) project is the largest resource for cataloguing gene function. Nonetheless, its use is not yet ubiquitous and is still fraught with pitfalls. In this review, we provide a short primer to the GO for bioinformaticians. We summarize important aspects of the structure of the ontology, describe sources and types of functional annotations, survey measures of GO annotation similarity, review typical uses of GO and discuss other important considerations pertaining to the use of GO in bioinformatics applications.
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