ReviewSeminars in cell & developmental biology2011
Thalamocortical dynamics of sleep: roles of purinergic neuromodulation.
Review in Seminars in cell & developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness.Scientific reports · 2025Article
- Subcortical volume alteration and correlation with social function under chlorpromazine versus clozapine treatment in schizophrenia.BMC psychiatry · 2025Article
- Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice.Cell reports. Medicine · 2024Article
- Low Levels of Adenosine and GDNF Are Potential Risk Factors for Parkinson's Disease with Sleep Disorders.Brain sciences · 2023Article
- The thalamus in psychosis spectrum disorder.Frontiers in neuroscience · 2023Article
- Adenosine Differentially Modulates Synaptic Transmission of Excitatory and Inhibitory Microcircuits in Layer 4 of Rat Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Visually Evoked 3-5 Hz Membrane Potential Oscillations Reduce the Responsiveness of Visual Cortex Neurons in Awake Behaving Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Interrogating the mouse thalamus to correct human neurodevelopmental disorders.Molecular psychiatry · 2017Review
- Decreasing sleep requirement with increasing numbers of neurons as a driver for bigger brains and bodies in mammalian evolution.Proceedings. Biological sciences · 2015Article
- Non-additive modulation of synaptic transmission by serotonin, adenosine, and cholinergic modulators in the sensory thalamus.Frontiers in cellular neuroscience · 2015Article
- Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.Molecular autism · 2015Article
- Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.Translational psychiatry · 2014Article
- Modulation of synaptic transmission by adenosine in layer 2/3 of the rat visual cortex in vitro.Neuroscience · 2014Article
- Drug-induced sleep: theoretical and practical considerations.Pflugers Archiv : European journal of physiology · 2012Review
- The sleep relay--the role of the thalamus in central and decentral sleep regulation.Pflugers Archiv : European journal of physiology · 2012Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Thalamocortical dynamics, the millisecond to second changes in activity of thalamocortical circuits, are central to perception, action and cognition. Generated by local circuitry and sculpted by neuromodulatory systems, these dynamics reflect the expression of vigilance states. In sleep, thalamocortical dynamics are thought to mediate "offline" functions including memory consolidation and synaptic scaling. Here, I discuss thalamocortical sleep dynamics and their modulation by the ascending arousal system and locally released neurochemicals. I focus on modulation of these dynamics by electrically silent astrocytes, highlighting the role of purinergic signaling in this glial form of communication. Astrocytes modulate cortical slow oscillations, sleep behavior, and sleep-dependent cognitive function. The discovery that astrocytes can modulate sleep dynamics and sleep-related behaviors suggests a new way of thinking about the brain, in which integrated circuits of neurons and glia control information processing and behavioral output.
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