ArticleBMC pediatrics2011
Breastfeeding and the risk of rotavirus diarrhea in hospitalized infants in Uganda: a matched case control study.
Article in BMC pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Rotavirus infection and breastfeeding practices among children under two: Findings from a tertiary hospital in Chattogram, Bangladesh (2018-20).IJID regions · 2025Article
- Article
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- Rotavirus A infection in children under five years old with a double health problem: undernutrition and diarrhoea - a cross-sectional study in four provinces of Mozambique.BMC infectious diseases · 2021Article
- Role of healthcare practitioners in rotavirus disease awareness and vaccination - insights from a survey among caregivers.Human vaccines & immunotherapeutics · 2020Article
- Use of post-graduate students' research in evidence informed health policies: a case study of Makerere University College of Health Sciences, Uganda.Health research policy and systems · 2018Article
- Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries.Clinical and vaccine immunology : CVI · 2017Review
- Rotavirus vaccine, breastfeeding, and other factors that could affect susceptibility to gastroenteritis in young children.Canadian journal of public health = Revue canadienne de sante publique · 2017Article
- Applying Rank Sum Ratio (RSR) to the Evaluation of Feeding Practices Behaviors, and Its Associations with Infant Health Risk in Rural Lhasa, Tibet.International journal of environmental research and public health · 2015Article
- Association between Severe Dehydration in Rotavirus Diarrhea and Exclusive Breastfeeding among Infants at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.Journal of tropical medicine · 2015Article
- Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study.BMC gastroenterology · 2014Article
- Effect of breastfeeding promotion interventions on cost-effectiveness of rotavirus immunization in Indonesia.BMC public health · 2013Article
- Nosocomial rotavirus gastroenterocolitis in a large tertiary paediatric hospital in Warsaw, 2006-2010.Archives of medical science : AMS · 2013Article
- Socio-demographic, Clinical and Laboratory Features of Rotavirus Gastroenteritis in Children Treated in Pediatric Clinic.Materia socio-medica · 2013Article
- Rotavirus infection among Sudanese children younger than 5 years of age: a cross sectional hospital-based study.The Pan African medical journal · 2013Article
- Vaccine-derived NSP2 segment in rotaviruses from vaccinated children with gastroenteritis in Nicaragua.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Article
- Characteristics of Rotavirus, ETEC, andJournal of primary care & community healthArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRotavirus is responsible for over 25 million outpatient visits, over 2 million hospitalizations and 527,000 deaths annually, worldwide. It is estimated that breastfeeding in accordance with the World Health Organization recommendations would save 1.45 million children's lives each year in the developing countries. The few studies that examined the effect of breastfeeding on rotavirus diarrhea produced conflicting results. This study aimed to determine the effect of breastfeeding on rotavirus diarrhea among admitted infants in Uganda.
methodsThe study was conducted in the Pediatrics medical emergency unit of a National Referral hospital during a peak incidence time for rotavirus from February to April 2008. It was an age matched case-control study with a ratio of 1:1. We consecutively enrolled infants presenting at the study site during this period whose caretakers consented to participate in the study. A minimum sample size of 90 pairs was adequate with power of 80% to detect a 30% decrease in breastfeeding rate among the cases assuming a breastfeeding rate of 80% in the controls. The infants with rotavirus positive results were the "cases". We used the commercial enzyme immunoassay kit (DAKO IDEIA™ rotavirus EIA detection kit) to diagnose the cases. The "controls" were admitted children with no diarrhea. We compared the cases and controls for antecedent breastfeeding patterns.
resultsNinety-one matched case-control age-matched pairs with an age caliper of one month were included in the analysis. Breastfeeding was not protective against rotavirus diarrhea (OR 1.08: 95% CI 0.52 - 2.25; p = 0.8) in the conditional logistic model.
conclusionsOur study findings did not reveal breastfeeding as protective against rotavirus diarrhea in infants. This suggests searching for other complementary preventive methods such as rotavirus vaccination and zinc supplementation to reduce the problem of rotavirus diarrhea in infants irrespective of their feeding practices.
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