Evidence map›Paper›PMID 21329431›Full record

ReviewExpert review of proteomics2011

Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms.

Marko Radulovic, Jasminka Godovac-Zimmermann

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of proteomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Microgravity and immune cells.Journal of the Royal Society, Interface · 2023
    Review
  2. Article
  3. Culture ofPathogens (Basel, Switzerland) · 2021
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marko RadulovicDivision of Medicine, University College London, 5 University Street, London WC1E 6JF, UK. marko@radulovic.net
Jasminka Godovac-Zimmermann
University College London · GB

Funding

Wellcome Trust 081879
6 · The paper itself

Abstract

The cytoskeleton is a cellular scaffolding system whose functions include maintenance of cellular shape, enabling cellular migration, division, intracellular transport, signaling and membrane organization. In addition, in immune cells, the cytoskeleton is essential for phagocytosis. Following the advances in proteomics technology over the past two decades, cytoskeleton proteome analysis in resting and activated immune cells has emerged as a possible powerful approach to expand our understanding of cytoskeletal composition and function. However, so far there have only been a handful of studies of the cytoskeleton proteome in immune cells. This article considers promising proteomics strategies that could augment our understanding of the role of the cytoskeleton in host-defense mechanisms.

Indexed as

ImmunityActinsAnimalsApoptosisCarrier ProteinsCytoskeletonElectrophoresis, Gel, Two-DimensionalHumansMacrophagesMicrotubulesPhagocytosisProteomeProteomicsSignal TransductionActinsCarrier ProteinsProteome

Identifiers

PMID21329431
PMCPMC4261605
OpenAlexW1989324405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.